{"id":13220,"date":"2025-04-08T13:34:13","date_gmt":"2025-04-08T09:34:13","guid":{"rendered":"https:\/\/newpharma.ge\/pharma_products\/%e1%83%b0%e1%83%94%e1%83%9b%e1%83%9d%e1%83%a5%e1%83%a1%e1%83%90%e1%83%91%e1%83%90%e1%83%9c%e1%83%98-hemoxaban\/"},"modified":"2025-06-11T10:19:34","modified_gmt":"2025-06-11T06:19:34","slug":"%e1%83%b0%e1%83%94%e1%83%9b%e1%83%9d%e1%83%a5%e1%83%a1%e1%83%90%e1%83%91%e1%83%90%e1%83%9c%e1%83%98-hemoxaban","status":"publish","type":"product","link":"https:\/\/newpharma.ge\/en\/pharma_products\/%e1%83%b0%e1%83%94%e1%83%9b%e1%83%9d%e1%83%a5%e1%83%a1%e1%83%90%e1%83%91%e1%83%90%e1%83%9c%e1%83%98-hemoxaban\/","title":{"rendered":"\u10f0\u10d4\u10db\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \/ HEMOXABAN"},"content":{"rendered":"<p><strong>\u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0<\/strong><\/p>\n<p><strong>\u10f0\u10d4\u10db\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 10\u10db\u10d2<\/strong><\/p>\n<p>\u10d4\u10e0\u10d7\u10d8 \u10e8\u10d4\u10db\u10dd\u10d2\u10d0\u10e0\u10e1\u10e3\u10da\u10d8 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d3\u10d8\u10e1:<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u00a0 BP \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 10\u10db\u10d2<\/p>\n<p>\u10e8\u10d4\u10db\u10d0\u10d5\u10e1\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0q.s.<\/p>\n<p>\u10e4\u10d4\u10e0\u10d8: \u10e0\u10d9\u10d8\u10dc\u10d8\u10e1 \u10ec\u10d8\u10d7\u10d4\u10da\u10d8 \u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 \u10d3\u10d0 \u10e2\u10d8\u10e2\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d8\u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 BP<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u10f0\u10d4\u10db\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 15\u10db\u10d2<\/strong><\/p>\n<p>\u10d4\u10e0\u10d7\u10d8 \u10e8\u10d4\u10db\u10dd\u10d2\u10d0\u10e0\u10e1\u10e3\u10da\u10d8 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d3\u10d8\u10e1:<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u00a0 BP \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 15\u10db\u10d2<\/p>\n<p>\u10e8\u10d4\u10db\u10d0\u10d5\u10e1\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0q.s.<\/p>\n<p>\u10e4\u10d4\u10e0\u10d8:\u10e0\u10d9\u10d8\u10dc\u10d8\u10e1 \u10ec\u10d8\u10d7\u10d4\u10da\u10d8 \u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 \u10d3\u10d0 \u10e2\u10d8\u10e2\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d8\u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 BP<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u10f0\u10d4\u10db\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 20\u10db\u10d2<\/strong><\/p>\n<p>\u10d4\u10e0\u10d7\u10d8 \u10e8\u10d4\u10db\u10dd\u10d2\u10d0\u10e0\u10e1\u10e3\u10da\u10d8 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d3\u10d8\u10e1:<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u00a0 BP \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 20\u10db\u10d2<\/p>\n<p>\u10e8\u10d4\u10db\u10d0\u10d5\u10e1\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0q.s.<\/p>\n<p>\u10e4\u10d4\u10e0\u10d8: \u10e0\u10d9\u10d8\u10dc\u10d8\u10e1 \u10ec\u10d8\u10d7\u10d4\u10da\u10d8 \u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 \u10d3\u10d0 \u10e2\u10d8\u10e2\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d8\u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 BP<\/p>\n<p><strong>\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d0\u10e0\u10d8\u10e1 Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10db\u10d0\u10e6\u10d0\u10da\u10e1\u10d4\u10da\u10d4\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0\u10d8 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d8 \u10de\u10d4\u10e0\u10dd\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d1\u10d8\u10dd\u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10d3\u10dd\u10d1\u10d8\u10d7. Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d0 \u10d0\u10e4\u10d4\u10e0\u10ee\u10d4\u10d1\u10e1 \u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d9\u10d0\u10e1\u10d9\u10d0\u10d3\u10d8\u10e1\u00a0 \u10e8\u10d8\u10d3\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10e0\u10d4 \u10d2\u10d6\u10d4\u10d1\u10e1, \u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10d8\u10e1 \u10e4\u10dd\u10e0\u10db\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10e1 \u10e9\u10d0\u10db\u10dd\u10e7\u10d0\u10da\u10d8\u10d1\u10d4\u10d1\u10d0\u10e1. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d0\u10e0 \u10d0\u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e0\u10d4\u10d1\u10e1 \u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10e1 (\u10d0\u10e5\u10e2\u10d8\u10d5\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8 II) \u10d3\u10d0 \u10d0\u10e0 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d6\u10d4.<\/p>\n<p><strong>\u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10d1\u10d8<\/strong><\/p>\n<p><em><u>\u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10d8<\/u><\/em><\/p>\n<p>\u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0 \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0\u10ea \u10d0\u10e6\u10d4\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0\u10d7 \u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d0, \u10d4\u10e0\u10d7\u10d8 \u10d0\u10dc \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10d2\u10e3\u10da\u10d8\u10e1 \u10e8\u10d4\u10d2\u10e3\u10d1\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e3\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10dd\u10d1\u10d0, \u10f0\u10d8\u10de\u10d4\u10e0\u10e2\u10d4\u10dc\u10d6\u10d8\u10d0, \u226575 \u10ec\u10da\u10d8\u10e1 \u10d0\u10e1\u10d0\u10d9\u10d8, \u10e8\u10d0\u10e5\u10e0\u10d8\u10d0\u10dc\u10d8 \u10d3\u10d8\u10d0\u10d1\u10d4\u10e2\u10d8, \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d8\u10da\u10d8 \u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8 \u10d0\u10dc \u10e2\u10e0\u10d0\u10dc\u10d6\u10d8\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10d8\u10e8\u10d4\u10db\u10d8\u10e3\u10e0\u10d8 \u10e8\u10d4\u10e2\u10d4\u10d5\u10d0.<\/p>\n<p>\u10e6\u10e0\u10db\u10d0 \u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10d8\u10e1\u10d0 (DVT) \u10d3\u10d0 \u10e4\u10d8\u10da\u10e2\u10d5\u10d8\u10e1 \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10d8\u10e1 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 (PE) \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e6\u10e0\u10db\u10d0 \u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e4\u10d8\u10da\u10e2\u10d5\u10d8\u10e1 \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10d8\u10e1 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0 \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8.<\/p>\n<p><em><u>\u10de\u10d4\u10d3\u10d8\u10d0\u10e2\u10e0\u10d8\u10e3\u10da\u10d8 \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d0<\/u><\/em><\/p>\n<p>\u10d5\u10d4\u10dc\u10e3\u10e0\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 (VTE) \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10d5\u10d4\u10dc\u10e3\u10e0\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 18 \u10ec\u10da\u10d0\u10db\u10d3\u10d4 \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10db\u10dd\u10d6\u10d0\u10e0\u10d3\u10d4\u10d1\u10e8\u10d8, 30 &#8211; 50 \u10d9\u10d2\u00a0 \u10e1\u10ee\u10d4\u10e3\u10da\u10d8\u10e1 \u10ec\u10dd\u10dc\u10d8\u10d7, \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1\u10d8 \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10d3\u10d0\u10dc \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 5 \u10d3\u10e6\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2.<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d4\u10e1\u10d8<\/strong><\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d0<\/strong><\/p>\n<p><u>\u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0<\/u><\/p>\n<p>\u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 20\u10db\u10d2 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da, \u10e0\u10d0\u10ea \u10d0\u10e1\u10d4\u10d5\u10d4\u00a0 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d0\u10e5\u10e1\u10d8\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u00a0\u10e1\u10d0\u10d3\u10e6\u10d4\u10e6\u10d0\u10db\u10d8\u10e1\u10dd \u10d3\u10dd\u10d6\u10d0\u10d0.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10d3\u10d4\u10e1 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d0\u10d3, \u10d8\u10db \u10de\u10d8\u10e0\u10dd\u10d1\u10d8\u10d7, \u10e0\u10dd\u10db \u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10de\u10e0\u10d4\u10d5\u10d4\u10dc\u10ea\u10d8\u10d8\u10e1 \u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10d4\u10da\u10d8 \u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10e1.<\/p>\n<p>\u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e2\u10dd\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10d3\u10d0\u10e3\u10e7\u10dd\u10d5\u10dc\u10d4\u10d1\u10da\u10d8\u10d5 \u10e3\u10dc\u10d3\u10d0 \u10db\u10d8\u10d8\u10e6\u10dd\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8, \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10d2\u10d0\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10dd\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10db\u10d4\u10dd\u10e0\u10d4 \u10d3\u10e6\u10d8\u10d3\u10d0\u10dc \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8\u10d0. \u10d3\u10dd\u10d6\u10d0 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dd\u10e0\u10db\u10d0\u10d2\u10d3\u10d4\u10e1 \u10d8\u10db\u10d0\u10d5\u10d4 \u10d3\u10e6\u10d4\u10e1 \u10d2\u10d0\u10db\u10dd\u10e2\u10dd\u10d5\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d0\u10e1\u10d0\u10dc\u10d0\u10d6\u10e6\u10d0\u10e3\u10e0\u10d4\u10d1\u10da\u10d0\u10d3.<\/p>\n<p><u>DVT-\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0, PE-\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 DVT-\u10e1\u10d0 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0<\/u><\/p>\n<p>\u10db\u10ec\u10d5\u10d0\u10d5\u10d4 DVT-\u10e1 \u10d0\u10dc PE-\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10ec\u10e7\u10d8\u10e1\u10e8\u10d8 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 15 \u10db\u10d2 \u10dd\u10e0\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 \u10e1\u10d0\u10db\u10d8 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8, \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db 20 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 DVT-\u10e1 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1 \u10db\u10d8\u10d6\u10dc\u10d8\u10d7.<\/p>\n<p>\u10db\u10d8\u10d6\u10d0\u10dc\u10e8\u10d4\u10ec\u10dd\u10dc\u10d8\u10da\u10d8\u10d0 \u10ee\u10d0\u10dc\u10db\u10dd\u10d9\u10da\u10d4 (\u10db\u10d8\u10dc\u10d8\u10db\u10e3\u10db 3 \u10d7\u10d5\u10d4) \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d8 \u10d2\u10d0\u10e0\u10d3\u10d0\u10db\u10d0\u10d5\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9-\u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10d7 (\u10db\u10d0\u10d2., \u10d1\u10dd\u10da\u10dd \u10d3\u10e0\u10dd\u10d8\u10e1 \u10e1\u10d4\u10e0\u10d8\u10dd\u10d6\u10e3\u10da\u10d8 \u10dd\u10de\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0 \u10d0\u10dc \u10e2\u10e0\u10d0\u10d5\u10db\u10d0) \u10de\u10e0\u10dd\u10d5\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 DVT \u10d0\u10dc PE-\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8. \u10db\u10d4\u10e2\u10d8 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10d2\u10d0\u10d7\u10d5\u10d0\u10da\u10d8\u10e1\u10ec\u10d8\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10de\u10e0\u10dd\u10d5\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 DVT \u10d0\u10dc PE-\u10d7\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3 \u10d2\u10d0\u10e0\u10d3\u10d0\u10db\u10d0\u10d5\u10d0\u10da \u10e0\u10d8\u10e1\u10d9 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d7\u10d0\u10dc, \u10d0\u10e0\u10d0\u10de\u10e0\u10dd\u10d5\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 DVT \u10d0\u10dc PE-\u10d7\u10d8, \u10d0\u10dc \u10d0\u10dc\u10d0\u10db\u10dc\u10d4\u10d6\u10e8\u10d8 DVT \u10d0\u10dc PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d8\u10e1\u10d0\u10e1.<\/p>\n<p>DVT-\u10e1 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10de\u10e0\u10d4\u10d5\u10d4\u10dc\u10ea\u10d8\u10d8\u10e1 \u10db\u10d8\u10d6\u10dc\u10d8\u10d7 (DVT-\u10e1 \u10d0\u10dc PE-\u10e1 \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 6 \u10d7\u10d5\u10d8\u10d0\u10dc\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2) \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 10 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8. DVT-\u10e1 \u10d0\u10dc PE-\u10e1 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10db\u10d0\u10d2., \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10d0\u10dc\u10db\u10ee\u10da\u10d4\u10d1\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc DVT-\u10e1 \u10d0\u10dc \u00a0PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10e4\u10dd\u10dc\u10d6\u10d4 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d3\u10dd\u10d6\u10d8\u10d7 10 \u10db\u10d2 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1, \u10db\u10d8\u10d6\u10d0\u10dc\u10e8\u10d4\u10ec\u10dd\u10dc\u10d8\u10da\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u00a0\u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10d5\u10dc\u10d0.<\/p>\n<p>\u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10e8\u10d4\u10e0\u10e9\u10d4\u10d5\u10d0 \u10d8\u10dc\u10d3\u10d8\u10d5\u10d8\u10d3\u10e3\u10d0\u10da\u10e3\u10e0\u10d0\u10d3 \u10e3\u10dc\u10d3\u10d0 \u10db\u10dd\u10ee\u10d3\u10d4\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10d4\u10da\u10d8\u10e1 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2.<\/p>\n<p><em>DVT-\u10e1 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0<\/em><\/p>\n<p><strong>\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d0: <\/strong>\u00a01-21 \u10d3\u10e6\u10d4<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10df\u10d8\u10db\u10d8:<\/strong> 15 \u10db\u10d2 \u10dd\u10e0\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8<\/p>\n<p><strong>\u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10e1\u10d0\u10d3\u10e6\u10d4\u10e6\u10d0\u10db\u10d8\u10e1\u10dd \u10d3\u10dd\u10d6\u10d0:<\/strong> 30\u10db\u10d2<\/p>\n<p><strong>\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d0: <\/strong>\u00a022 \u10d3\u10e6\u10d8\u10d3\u10d0\u10dc<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10df\u10d8\u10db\u10d8:<\/strong> 20 \u10db\u10d2 \u10dd\u10e0\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8<\/p>\n<p><strong>\u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10e1\u10d0\u10d3\u10e6\u10d4\u10e6\u10d0\u10db\u10d8\u10e1\u10dd \u10d3\u10dd\u10d6\u10d0:<\/strong> 20\u10db\u10d2<\/p>\n<p><em>DVT-\u10e1\u10d0 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0<\/em><\/p>\n<p><strong>\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d0: <\/strong>\u00a0DVT-\u10e1 \u10d0\u10dc PE-\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 6 \u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10df\u10d8\u10db\u10d8:<\/strong> 10 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d0\u10dc 20 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8<\/p>\n<p><strong>\u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10e1\u10d0\u10d3\u10e6\u10d4\u10e6\u10d0\u10db\u10d8\u10e1\u10dd \u10d3\u10dd\u10d6\u10d0:<\/strong> 10\u10db\u10d2 \u10d0\u10dc 20\u10db\u10d2<\/p>\n<p>21 \u10d3\u10e6\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 15\u10db\u10d2-\u10d3\u10d0\u10dc 20\u10db\u10d2 \u10d3\u10dd\u10d6\u10d0\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1 \u10db\u10ee\u10d0\u10e0\u10d3\u10d0\u10e1\u10d0\u10ed\u10d4\u10e0\u10d0\u10d3 \u10ee\u10d4\u10da\u10db\u10d8\u10e1\u10d0\u10ec\u10d5\u10d3\u10dd\u10db\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 DVT \/ PE-\u10e1 \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1\u10d8 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 4-\u10d9\u10d5\u10d8\u10e0\u10d8\u10d0\u10dc\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10e5\u10d4\u10db\u10d0.<\/p>\n<p>15 \u10db\u10d2 2-\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e4\u10d0\u10d6\u10d0\u10e8\u10d8 (1 \u2013 21 \u10d3\u10e6\u10d4) \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e2\u10dd\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10d3\u10d0\u10e3\u10e7\u10dd\u10d5\u10dc\u10d4\u10d1\u10da\u10d8\u10d5 \u10e3\u10dc\u10d3\u10d0 \u10db\u10d8\u10d8\u10e6\u10dd\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8, \u10e0\u10d0\u10d7\u10d0 \u10e3\u10d6\u10e0\u10e3\u10dc\u10d5\u10d4\u10da\u10e7\u10dd\u10e1 30 \u10db\u10d2 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10d3\u10e6\u10d4\u10e8\u10d8. \u10d0\u10db \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d0\u10d3 \u10dd\u10e0\u10d8 15 \u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0. \u10db\u10dd\u10db\u10d3\u10d4\u10d5\u10dc\u10dd \u10d3\u10e6\u10d4\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10dd\u10e1 \u10e0\u10d4\u10d2\u10e3\u10da\u10d0\u10e0\u10e3\u10da\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 15\u10db\u10d2 2-\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8\u10d0.<\/p>\n<p>\u10d3\u10e6\u10d4\u10e8\u10d8 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e4\u10d0\u10d6\u10d0\u10e8\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e2\u10dd\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10d3\u10d0\u10e3\u10e7\u10dd\u10d5\u10dc\u10d4\u10d1\u10da\u10d8\u10d5 \u10e3\u10dc\u10d3\u10d0 \u10db\u10d8\u10d8\u10e6\u10dd\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d3\u10d0 \u10d2\u10d0\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10dd\u10e1 \u10db\u10d4\u10dd\u10e0\u10d4 \u10d3\u10e6\u10d4\u10e1 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10db\u10d8\u10e6\u10d4\u10d1\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8\u10d0. \u10d3\u10dd\u10d6\u10d0 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dd\u10e0\u10db\u10d0\u10d2\u10d3\u10d4\u10e1 \u10d8\u10db\u10d0\u10d5\u10d4 \u10d3\u10e6\u10d4\u10e1 \u10d2\u10d0\u10db\u10dd\u10e2\u10dd\u10d5\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d0\u10e1\u10d0\u10dc\u10d0\u10d6\u10e6\u10d0\u10e3\u10e0\u10d4\u10d1\u10da\u10d0\u10d3.<\/p>\n<p><u>K \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d0\u10d2\u10dd\u10dc\u10d8\u10e1\u10e2\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc (VKA) \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d0<\/u><\/p>\n<p>\u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\u10e1 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0: VKA \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10d8\u10ec\u10e7\u10dd\u10e1, \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea \u10e1\u10d0\u10d4\u10e0\u10d7\u10d0\u10e8\u10dd\u10e0\u10d8\u10e1\u10dd \u10dc\u10dd\u10e0\u10db\u10d0\u10da\u10d8\u10d6\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10d0\u10dc\u10d0\u10e4\u10d0\u10e0\u10d3\u10dd\u10d1\u10d0 (INR) \u10d0\u10e0\u10d8\u10e1 \u2264 3.0.<\/p>\n<p>DVT-\u10d8\u10e1, PE-\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0: VKA \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10d8\u10ec\u10e7\u10dd\u10e1, \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea INR \u10d8\u10e5\u10dc\u10d4\u10d1\u10d0 \u2264 2,5.<\/p>\n<p>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 VKA-\u10d3\u10d0\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e7\u10d5\u10d0\u10dc\u10d8\u10e1\u10d0\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0 INR-\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10e0\u10e3 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10d0. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 INR \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e1\u10d0\u10dc\u10d3\u10dd.<\/p>\n<p><u>15\u10db\u10d2 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d3\u10d0\u10dc K \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8\u10e1\u10d0\u10dc\u10e2\u10d0\u10d2\u10dd\u10dc\u10d8\u10e1\u10e2\u10d4\u10d1\u10d6\u10d4 (VKA) \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d0<\/u><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 15\u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc VKA-\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1\u10d0\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d0\u10e0\u10d0\u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d0. \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e3\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e3\u10d6\u10e0\u10e3\u10dc\u10d5\u10d4\u10da\u10e7\u10dd\u10e4\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1\u10d0\u10e1. \u10e3\u10dc\u10d3\u10d0 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10dd\u10e1, \u10e0\u10dd\u10db \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10db\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 INR.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d3\u10d0\u10dc VKA-\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1\u10d0\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10db\u10d8\u10d8\u10e6\u10d4\u10d1\u10d0 VKA-\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3, \u10e1\u10d0\u10dc\u10d0\u10db INR \u10d0\u10e0 \u10db\u10d8\u10d0\u10e6\u10ec\u10d4\u10d5\u10e1 \u2265 2.0-\u10e1. \u10d2\u10d0\u10e0\u10d3\u10d0\u10db\u10d0\u10d5\u10d0\u10da\u10d8 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8\u10e1 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 \u10dd\u10e0\u10d8 \u10d3\u10e6\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 VKA-\u10e1 \u10e1\u10e2\u10d0\u10dc\u10d3\u10d0\u10e0\u10e2\u10e3\u10da\u10d8 \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1\u10d8 \u10d3\u10dd\u10d6\u10d0, \u10e0\u10d0\u10e1\u10d0\u10ea \u10db\u10dd\u10f0\u10e7\u10d5\u10d4\u10d1\u10d0 VKA-\u10e1 \u10d3\u10dd\u10d6\u10d0 INR-\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0\u10d6\u10d4 \u10d3\u10d0\u10e7\u10e0\u10d3\u10dc\u10dd\u10d1\u10d8\u10d7. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 15\u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 VKA\u2013\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 INR \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10d8\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10dd\u10e1 \u10ec\u10d8\u10dc\u10d0 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 24 \u10e1\u10d0\u10d0\u10d7\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0\u10db\u10d3\u10d4. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 INR-\u10d8\u10e1 \u10e1\u10d0\u10d8\u10db\u10d4\u10d3\u10dd \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10dc\u10ee\u10dd\u10e0\u10ea\u10d8\u10d4\u10da\u10d3\u10d4\u10e1 \u10d1\u10dd\u10da\u10dd \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 24 \u10e1\u10d0\u10d0\u10d7\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2.<\/p>\n<p><u>\u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d0<\/u><\/p>\n<p>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10e1, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10d8\u10ec\u10e7\u10dd\u10e1 0-2 \u10e1\u10d0\u10d0\u10d7\u10d8\u10d7 \u10d0\u10d3\u10e0\u10d4 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2\u10d8 \u10d3\u10d0\u10d2\u10d4\u10d2\u10db\u10d8\u10da\u10d8 \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10e8\u10d4\u10e7\u10d5\u10d0\u10dc\u10d8\u10e1 \u10d3\u10e0\u10dd\u10db\u10d3\u10d4 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d3\u10d0\u10d1\u10d0\u10da\u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10db\u10d0\u10e1\u10d8\u10e1 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8) \u10d0\u10dc \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10e3\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8 \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10e1 \u10db\u10dd\u10db\u10d4\u10dc\u10e2\u10e8\u10d8 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d0\u10e0\u10d0\u10e4\u10e0\u10d0\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10d8\u10dc\u10e2\u10e0\u10d0\u10d5\u10d4\u10dc\u10e3\u10e0\u10d8 \u10e8\u10d4\u10e7\u10d5\u10d0\u10dc\u10d0).<\/p>\n<p><u>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d3\u10d0\u10dc \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d0<\/u><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1 \u10d3\u10d0 \u10de\u10d0\u10e0\u10d4\u10dc\u10e2\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d8\u10e1 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10dc\u10d0\u10ea\u10d5\u10da\u10d0\u10d3.<\/p>\n<p><u>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d7\u10d0 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10ef\u10d2\u10e3\u10e4\u10d4\u10d1\u10d8<\/u><\/p>\n<p><strong>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0<\/strong><\/p>\n<p>\u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10eb\u10d8\u10db\u10d4 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 15 &#8211; 29 \u10db\u10da\/\u10ec\u10d7) \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10de\u10da\u10d0\u10d6\u10db\u10e3\u10e0\u10d8 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10dc\u10d0\u10d3 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da\u10d8\u10d0. \u10d0\u10db\u10d8\u10e2\u10dd\u10db, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 20\u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8 \u10d0\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d8\u10d7 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8. \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8\u10d7 &lt; 15 \u10db\u10da\/\u10ec\u10d7.<\/p>\n<p>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd (\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 30-49 \u10db\u10da\/\u10ec\u10d7) \u10d0\u10dc \u10db\u10eb\u10d8\u10db\u10d4 (\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 15-29 \u10db\u10da\/\u10ec\u10d7) \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2\u10d8 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1:<\/p>\n<ul>\n<li>\u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0\u10ea \u10d0\u10e6\u10d4\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0\u10d7 \u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d0, \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 15 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8.<\/li>\n<li>DVT-\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3, PE-\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0 DVT-\u10e1\u10d0 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1: \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d8\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0 15\u10db\u10d2 2-\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 3 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8. \u10d0\u10db\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10d7\u10e3 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 20\u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8, \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10d8\u10ee\u10d8\u10da\u10d4\u10d1\u10dd\u10d3\u10d4\u10e1 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0 20\u10db\u10d2-\u10d3\u10d0\u10dc \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 15 \u10db\u10d2-\u10db\u10d3\u10d4 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8, \u10d7\u10e3 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10e8\u10d8 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10d0\u10e6\u10d4\u10db\u10d0\u10e2\u10d4\u10d1\u10d0 DVT-\u10e1\u10d0 \u10d3\u10d0 PE-\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10e1. 15\u10db\u10d2-\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d0 \u10d4\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10d0 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10e1\u10d8\u10e2\u10e3\u10d0\u10ea\u10d8\u10d0\u10e8\u10d8.<\/li>\n<\/ul>\n<p>\u10d7\u10e3 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0\u10d0 10 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8, \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d9\u10dd\u10e0\u10d4\u10e5\u10ea\u10d8\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d8 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 50 &#8211; 80 \u10db\u10da\/\u10ec\u10d7) \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d9\u10dd\u10e0\u10d4\u10e5\u10ea\u10d8\u10d0\u00a0\u00a0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10e6\u10d5\u10d8\u10eb\u10da\u10d8\u10e1<\/strong> <strong>\u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e3\u10d9\u10e3\u10dc\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10d0 \u10e6\u10d5\u10d8\u10eb\u10da\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10dd\u10de\u10d0\u10d7\u10d8\u10d0\u10e1 \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10e1, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 Child Pugh -\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7 B \u10d3\u10d0 C \u10ea\u10d8\u10e0\u10dd\u10d6\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8.<\/p>\n<p><strong>\u10ee\u10d0\u10dc\u10d3\u10d0\u10d6\u10db\u10e3\u10da\u10d4\u10d1\u10d8 <\/strong><\/p>\n<p>\u10d3\u10dd\u10d6\u10d8\u10e1 \u10d9\u10dd\u10e0\u10d4\u10e5\u10ea\u10d8\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10e1\u10ee\u10d4\u10e3\u10da\u10d8\u10e1 \u10ec\u10dd\u10dc\u10d0<\/strong><\/p>\n<p>\u10d3\u10dd\u10d6\u10d8\u10e1 \u10d9\u10dd\u10e0\u10d4\u10e5\u10ea\u10d8\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10e1\u10e5\u10d4\u10e1\u10d8<\/strong><\/p>\n<p>\u10d3\u10dd\u10d6\u10d8\u10e1 \u10d9\u10dd\u10e0\u10d4\u10e5\u10ea\u10d8\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10de\u10d4\u10d3\u10d8\u10d0\u10e2\u10e0\u10d8\u10e3\u10da\u10d8 \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d0<\/strong><\/p>\n<p>18 \u10ec\u10da\u10d0\u10db\u10d3\u10d4 \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8. \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, 18 \u10ec\u10da\u10d0\u10db\u10d3\u10d4 \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d0<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d8\u10dc\u10d8\u10e8\u10dc\u10dd\u10e1 \u10d0\u10dc \u10d2\u10d0\u10d2\u10e0\u10eb\u10d4\u10da\u10d3\u10d4\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10e1\u10ed\u10d8\u10e0\u10d3\u10d4\u10d7 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d0.<\/p>\n<p>\u10e2\u10e0\u10d0\u10dc\u10e1\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10d4\u10e5\u10dd\u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d2\u10e0\u10d0\u10e4\u10d8\u10d8\u10d7 (TEE) \u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d8 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10d3\u10e0\u10d4 \u10d0\u10e0 \u10d8\u10e6\u10d4\u10d1\u10d3\u10dc\u10d4\u10dc \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10e1, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10d8\u10ec\u10e7\u10dd\u10e1 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d0\u10db\u10d3\u10d4 \u10db\u10d8\u10dc\u10d8\u10db\u10e3\u10db 4 \u10e1\u10d0\u10d0\u10d7\u10d8\u10d7 \u10d0\u10d3\u10e0\u10d4, \u10e0\u10d0\u10d7\u10d0 \u10e3\u10d6\u10e0\u10e3\u10dc\u10d5\u10d4\u10da\u10e7\u10dd\u10e4\u10d8\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10d0\u10d3\u10d4\u10d9\u10d5\u10d0\u10e2\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10d0. \u10d7\u10d8\u10d7\u10dd\u10d4\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d8\u10e1 \u10d3\u10d0\u10ec\u10e7\u10d4\u10d1\u10d0\u10db\u10d3\u10d4 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10e0\u10ec\u10db\u10e3\u10dc\u10d3\u10d4\u10d7, \u10e0\u10dd\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10db\u10d8\u10d8\u10e6\u10dd \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7. \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10ec\u10e7\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d2\u10d0\u10d3\u10d0\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10ee\u10d4\u10d3\u10d5\u10d4\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10d7\u10d5\u10d0\u10da\u10d8\u10e1\u10ec\u10d8\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 \u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10d5\u10d4\u10e0\u10e1\u10d8\u10d0.<\/p>\n<p><strong>\u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 <\/strong><strong>\u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 PCI (\u10de\u10d4\u10e0\u10d9\u10e3\u10e2\u10d0\u10dc\u10e3\u10da\u10d8 \u10d9\u10dd\u10e0\u10dd\u10dc\u10d0\u10e0\u10e3\u10da\u10d8 \u10d8\u10dc\u10e2\u10d4\u10e0\u10d5\u10d4\u10dc\u10ea\u10d8\u10d0) \u10e1\u10e2\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d3\u10d0\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10d7<\/strong><\/p>\n<p>\u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 15 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 (\u10d0\u10dc 10 \u10db\u10d2 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 [\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 30 &#8211; 49 \u10db\u10da\/\u10ec\u10d7]) P2Y12-\u10d8\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10db\u10d0\u10e5\u10e1\u10d8\u10db\u10e3\u10db 12 \u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d4\u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d0\u10d7 \u10de\u10d4\u10e0\u10dd\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 PCI \u10e1\u10e2\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d7\u10d0\u10d5\u10e1\u10d4\u10d1\u10d8\u10d7.<\/p>\n<p><strong><u>\u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d4\u10e1\u10d8<\/u><\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d2\u10d0\u10dc\u10d9\u10e3\u10d7\u10d5\u10dc\u10d8\u10da\u10d8\u10d0 \u10de\u10d4\u10e0\u10dd\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1.<\/p>\n<p>\u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8 \u10db\u10d8\u10d8\u10e6\u10d4\u10d1\u10d0 \u10e1\u10d0\u10d9\u10d5\u10d4\u10d1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3.<\/p>\n<p><strong>\u10e3\u10d9\u10e3\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d2\u10e0\u10eb\u10dc\u10dd\u10d1\u10d4\u10da\u10dd\u10d1\u10d0 \u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10db\u10d4 \u10d3\u10d0\u10db\u10ee\u10db\u10d0\u10e0\u10d4 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7.<\/p>\n<p>\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0.<\/p>\n<p>\u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0 \u10d0\u10dc \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0, \u10d7\u10e3 \u10d8\u10d2\u10d8 \u10db\u10d8\u10e9\u10dc\u10d4\u10e3\u10da\u10d8\u10d0 \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10e0\u10d8\u10e1\u10d9\u10d0\u10d3. \u10d4\u10e1 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10db\u10dd\u10d8\u10ea\u10d0\u10d5\u10d3\u10d4\u10e1 \u10db\u10d8\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4 \u10d0\u10dc \u10d0\u10ee\u10da\u10dd \u10ec\u10d0\u10e0\u10e1\u10e3\u10da\u10e8\u10d8 \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d8\u10da \u10d9\u10e3\u10ed-\u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10e1 \u10ec\u10e7\u10da\u10e3\u10da\u10e1, \u00a0\u10d0\u10d5\u10d7\u10d5\u10d8\u10e1\u10d4\u10d1\u10d8\u10d0\u10dc\u10d8 \u10e1\u10d8\u10db\u10e1\u10d8\u10d5\u10dc\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d0\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10d7, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc \u10d6\u10e3\u10e0\u10d2\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10ee\u10d0\u10da \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0\u10e1, \u10d0\u10ee\u10da\u10dd \u10ec\u10d0\u10e0\u10e1\u10e3\u10da\u10e8\u10d8 \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d8\u10da \u10dd\u10de\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d6\u10d4, \u10d6\u10e3\u10e0\u10d2\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e1\u10d0 \u10d7\u10e3 \u10d7\u10d5\u10d0\u10da\u10d6\u10d4, \u10d0\u10ee\u10da\u10dd \u10ec\u10d0\u10e0\u10e1\u10e3\u10da\u10e8\u10d8 \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d8\u10da \u10d8\u10dc\u10e2\u10e0\u10d0\u10d9\u10e0\u10d0\u10dc\u10d8\u10d0\u10da\u10e3\u10e0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0\u10e1, \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da \u10d0\u10dc \u10e1\u10d0\u10d4\u10ed\u10d5\u10dd \u10e1\u10d0\u10e7\u10da\u10d0\u10de\u10d0\u10d5\u10d8 \u10db\u10d8\u10da\u10d8\u10e1 \u10d5\u10d0\u10e0\u10d8\u10d9\u10dd\u10d6\u10e3\u10da\u10d8 \u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d2\u10d0\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0\u10e1, \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10dd\u10d5\u10d4\u10dc\u10e3\u10e0 \u10db\u10d0\u10da\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d4\u10d1\u10e1, \u10e1\u10d8\u10e1\u10ee\u10da\u10eb\u10d0\u10e0\u10e6\u10d5\u10d7\u10d0 \u10d0\u10dc\u10d4\u10d5\u10e0\u10d8\u10d6\u10db\u10d4\u10d1\u10e1 \u10d0\u10dc \u10d3\u10d8\u10d3 \u10d8\u10dc\u10e2\u10e0\u10d0\u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0 \u10d0\u10dc \u10d8\u10dc\u10e2\u10e0\u10d0\u10ea\u10d4\u10e0\u10d4\u10d1\u10e0\u10d0\u10da\u10e3\u10e0 \u10d5\u10d0\u10e1\u10d9\u10e3\u10da\u10e3\u10e0 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10e1.<\/p>\n<p>\u10dc\u10d4\u10d1\u10d8\u10e1\u10db\u10d8\u10d4\u10e0 \u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d7\u10d0\u10dc (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d0\u10e0\u10d0\u10e4\u10e0\u10d0\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8 (UFH), \u10d3\u10d0\u10d1\u10d0\u10da\u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10ec\u10dd\u10dc\u10d8\u10e1 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d4\u10d1\u10d8 (\u10d4\u10dc\u10dd\u10e5\u10e1\u10d0\u10de\u10d0\u10e0\u10d8\u10dc\u10d8, \u10d3\u10d0\u10da\u10e2\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8 \u10d3\u10d0 \u10d0.\u10e8.), \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d8 (\u10e4\u10dd\u10dc\u10d3\u10d0\u10de\u10d0\u10e0\u10d8\u10dc\u10e3\u10e5\u10e1\u10d8 \u10d3\u10d0 \u10d0.\u10e8.)) \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0, \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10e8\u10d4\u10ea\u10d5\u10da\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d3\u10d0 \u10d0\u10dc \u10d0\u10e0\u10d0\u10e4\u10e0\u10d0\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d0\u10dc\u10d8\u10e8\u10d5\u10dc\u10d8\u10e1\u10d0\u10e1 \u10d3\u10dd\u10d6\u10d4\u10d1\u10d8\u10d7, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e6\u10d8\u10d0 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d5\u10d4\u10dc\u10e3\u10e0\u10d8 \u10d0\u10dc \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10dc\u10d0\u10e0\u10e9\u10e3\u10dc\u10d4\u10d1\u10da\u10d0\u10d3.<\/p>\n<p>\u10e6\u10d5\u10d8\u10eb\u10da\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10dd\u10de\u10d0\u10d7\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d7\u10d0\u10dc, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10ea\u10d8\u10e0\u10dd\u10d6\u10e3\u10da \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 Child Pugh \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7 B \u10d3\u10d0 C \u10d9\u10da\u10d0\u10e1\u10d8\u10d7.<\/p>\n<p>\u10dd\u10e0\u10e1\u10e3\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10eb\u10e3\u10eb\u10e3\u10d7\u10d8 \u10d9\u10d5\u10d4\u10d1\u10d0.<\/p>\n<p><strong>\u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d8\u10d7\u10d8\u10d7\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10d6\u10dd\u10db\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10db\u10d7\u10d4\u10da\u10d8 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d9\u10d5\u10d8\u10e0\u10d5\u10d4\u10d1\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10e3\u10da\u10d8 \u10de\u10e0\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3.<\/p>\n<p><strong>\u10f0\u10d4\u10db\u10dd\u10e0\u10d0\u10d2\u10d8\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8<\/strong><\/p>\n<p>\u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d0\u10d3, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1, \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e7\u10d5\u10dc\u10d4\u10dc \u10db\u10d9\u10d0\u10ea\u10e0\u10d8 \u10db\u10dd\u10dc\u10d8\u10e2\u10dd\u10e0\u10d8\u10dc\u10d2\u10d8\u10e1 \u10e5\u10d5\u10d4\u10e8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd. \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d8\u10d7 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e8\u10d8. \u10db\u10eb\u10d8\u10db\u10d4 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1.<\/p>\n<p>\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8 \u10da\u10dd\u10e0\u10ec\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10e0\u10e1\u10d8\u10d3\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10ea\u10ee\u10d5\u10d8\u10e0\u10d8\u10d3\u10d0\u10dc, \u10e6\u10e0\u10eb\u10d8\u10da\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc, \u10d9\u10e3\u10ed-\u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10d3\u10d0\u10dc, \u10e8\u10d0\u10e0\u10d3-\u10e1\u10d0\u10e1\u10e5\u10d4\u10e1\u10dd \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10d3\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d5\u10d0\u10d2\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d4\u10dc\u10e1\u10e2\u10e0\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8) \u10d3\u10d0 \u10d0\u10dc\u10d4\u10db\u10d8\u10d0 \u10e3\u10e4\u10e0\u10dd \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1\u10d0\u10e1 VKA-\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7. \u10d0\u10db\u10e0\u10d8\u10d2\u10d0\u10d3, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d3\u10d0, \u10e4\u10d0\u10e0\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e1\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10d3 \u10d3\u10d0 \u10d0\u10e8\u10d9\u10d0\u10e0\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10e4\u10d0\u10e1\u10d4\u10d1\u10da\u10d0\u10d3 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10e6\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10f0\u10d4\u10db\u10dd\u10d2\u10da\u10dd\u10d1\u10d8\u10dc\u10d8\u10e1\/\u10f0\u10d4\u10db\u10d0\u10e2\u10dd\u10d9\u10e0\u10d8\u10e2\u10d8\u10e1 \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8.<\/p>\n<p>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10e5\u10d5\u10d4-\u10ef\u10d2\u10e3\u10e4\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e5\u10d5\u10d4\u10db\u10dd\u10d7 \u10d0\u10e0\u10d8\u10e1 \u10d0\u10e6\u10ec\u10d4\u10e0\u10d8\u10da\u10d8, \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e5\u10d5\u10d4\u10e8\u10d0\u10d0. \u10d0\u10e1\u10d4\u10d7 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10ec\u10e7\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d0\u10dc\u10d4\u10db\u10d8\u10d8\u10e1 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d2\u10e3\u10da\u10d3\u10d0\u10d2\u10e3\u10da\u10dd \u10db\u10dd\u10dc\u10d8\u10e2\u10dd\u10e0\u10d8\u10dc\u10d2\u10d8.<\/p>\n<p>\u10f0\u10d4\u10db\u10dd\u10d2\u10da\u10dd\u10d1\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10ec\u10dc\u10d4\u10d5\u10d8\u10e1 \u10dc\u10d4\u10d1\u10d8\u10e1\u10db\u10d8\u10d4\u10e0\u10d8 \u10d0\u10e3\u10ee\u10e1\u10dc\u10d4\u10da\u10d8 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e3\u10d1\u10dc\u10d8\u10e1 \u10eb\u10d8\u10d4\u10d1\u10d0.<\/p>\n<p>\u10db\u10d8\u10e3\u10ee\u10d4\u10d3\u10d0\u10d5\u10d0\u10d3 \u10d8\u10db\u10d8\u10e1\u10d0, \u10e0\u10dd\u10db \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10e1 \u10d4\u10e5\u10e1\u10de\u10dd\u10d6\u10d8\u10ea\u10d8\u10d8\u10e1 \u10e0\u10e3\u10e2\u10d8\u10dc\u10e3\u10da \u10db\u10dd\u10dc\u10d8\u10e2\u10dd\u10e0\u10d8\u10dc\u10d2\u10e1, \u10d2\u10d0\u10db\u10dd\u10dc\u10d0\u10d9\u10da\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10dd\u10d6\u10d8\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10ea\u10dd\u10d3\u10dc\u10d0\u10db \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10db\u10dd\u10d0\u10ee\u10d3\u10d8\u10dc\u10dd\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d2\u10d0\u10d3\u10d0\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10d6\u10d4, \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d0\u10dc \u10d2\u10d0\u10d3\u10d0\u10e3\u10d3\u10d4\u10d1\u10d4\u10da\u10d8 \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10d9\u10d0\u10da\u10d8\u10d1\u10e0\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc\u10e2\u10d8-Xa \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10e0\u10d8\u10d5\u10d8 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8\u10d7.<\/p>\n<p><strong>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0<\/strong><\/p>\n<p>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10eb\u10d8\u10db\u10d4 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (\u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8 &lt; 30 \u10db\u10da\/\u10ec\u10d7) \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4 \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10dc\u10d0\u10d3 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 (\u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 1,6-\u10ef\u10d4\u10e0), \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 15 \u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d8\u10d7 \u10d8\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8\u10d7 15 &#8211; 29\u10db\u10da\/\u10ec\u10d7. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d9\u10e0\u10d4\u10d0\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10e0\u10d4\u10dc\u10e1\u10d8\u10d7 &lt; 15 \u10db\u10da\/\u10ec\u10d7.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 15 \u10db\u10d2 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d8\u10d7 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e1\u10ee\u10d5\u10d0 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d6\u10e0\u10d3\u10d8\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e8\u10d8.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d0\u10d3 \u10d2\u10d0\u10d3\u10d8\u10d0\u10dc\u00a0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1 \u10d0\u10d6\u10dd\u10da\u10d8\u10e1 \u10ef\u10d2\u10e3\u10e4\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10db\u10d8\u10d9\u10dd\u10d6\u10e3\u10e0\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7 (\u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10d9\u10d4\u10e2\u10dd\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8, \u10d8\u10e2\u10e0\u10d0\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8, \u10d5\u10dd\u10e0\u10d8\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8 \u10d3\u10d0 \u10de\u10dd\u10d6\u10d0\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8) \u10d0\u10dc \u10d0\u10d8\u10d5-\u10d8\u10e1 \u10de\u10e0\u10dd\u10e2\u10d4\u10d0\u10d6\u10d0\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10d7 (\u10db\u10d0\u10d2. \u10e0\u10d8\u10e2\u10dd\u10dc\u10d0\u10d5\u10d8\u10e0\u10d8). \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d8 \u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea CYP3A4, \u10d0\u10e1\u10d4\u10d5\u10d4 P-gp \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10d3\u10d0, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, \u10db\u10d0\u10d7 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d6\u10d0\u10e0\u10d3\u10dd\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10de\u10da\u10d0\u10d6\u10db\u10e3\u10e0\u10d8 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d6\u10dd\u10db\u10d8\u10d7 (\u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 2.6-\u10ef\u10d4\u10e0), \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8.<\/p>\n<p><strong>\u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10e0\u10d8\u10e1\u10d9\u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10e3\u10da\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d0\u10d3, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0:<\/p>\n<ul>\n<li>\u10d7\u10d0\u10dc\u10d3\u10d0\u10e7\u10dd\u10da\u10d8\u10da\u10d8 \u10d0\u10dc \u10e8\u10d4\u10eb\u10d4\u10dc\u10d8\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8<\/li>\n<li>\u10d0\u10e0\u10d0\u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10d3\u10d8 \u10db\u10eb\u10d8\u10db\u10d4 \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10f0\u10d8\u10de\u10d4\u10e0\u10e2\u10d4\u10dc\u10d6\u10d8\u10d0<\/li>\n<li>\u10d9\u10e3\u10ed-\u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10e1 \u10e2\u10e0\u10d0\u10e5\u10e2\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10ec\u10e7\u10da\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d4\u10e8\u10d4, \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0, \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8, \u10d2\u10d0\u10e1\u10e2\u10e0\u10d8\u10e2\u10d8 \u10d3\u10d0 \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10d8)<\/li>\n<li>\u10d5\u10d0\u10e1\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e2\u10d8\u10dc\u10dd\u10de\u10d0\u10d7\u10d8\u10d0<\/li>\n<li>\u10d1\u10e0\u10dd\u10dc\u10e5\u10dd\u10d4\u10e5\u10e2\u10d0\u10d6\u10d8\u10d0 \u10d0\u10dc \u10d0\u10dc\u10d0\u10db\u10dc\u10d4\u10d6\u10e8\u10d8 \u10de\u10e3\u10da\u10db\u10dd\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0<\/li>\n<\/ul>\n<p><strong>\u10d2\u10e3\u10da\u10d8\u10e1 \u10e1\u10d0\u10e0\u10e5\u10d5\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d7\u10d4\u10d6\u10d8\u10e0\u10d4\u10d1\u10d0<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d8\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10db\u10d0\u10ea \u10d0\u10ee\u10da\u10dd \u10ec\u10d0\u10e0\u10e1\u10e3\u10da\u10e8\u10d8 \u10d2\u10d0\u10d8\u10d9\u10d4\u10d7\u10d4\u10e1 \u10d0\u10dd\u10e0\u10e2\u10d8\u10e1 \u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10d8\u10e1 \u10e2\u10e0\u10d0\u10dc\u10e1\u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10e3\u10da\u10d8 \u10d8\u10db\u10de\u10da\u10d0\u10dc\u10e2\u10d0\u10ea\u10d8\u10d0 (TAVR). \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d2\u10d0\u10d9\u10d4\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e5\u10d5\u10d7 \u10d2\u10e3\u10da\u10d8\u10e1 \u10e1\u10d0\u10e0\u10e5\u10d5\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d7\u10d4\u10d6\u10d8\u10e0\u10d4\u10d1\u10d0; \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d0\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0 \u10d0\u10d3\u10d4\u10e5\u10d5\u10d0\u10e2\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e3\u10d6\u10e0\u10e3\u10dc\u10d5\u10d4\u10da\u10e7\u10dd\u10e4\u10d8\u10e1 \u10db\u10ee\u10d0\u10e0\u10d3\u10d0\u10db\u10ed\u10d4\u10e0\u10d8 \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d0 \u10d0\u10e0 \u10db\u10dd\u10d8\u10de\u10dd\u10d5\u10d4\u10d1\u10d0. \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 \u10d0\u10dc\u10e2\u10d8\u10e4\u10dd\u10e1\u10e4\u10dd\u10da\u10d8\u10de\u10d8\u10d3\u10e3\u10e0\u10d8 \u10e1\u10d8\u10dc\u10d3\u10e0\u10dd\u10db\u10d8\u10d7<\/strong><\/p>\n<p>\u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0\u10d8 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10d4\u10e0\u10dd\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8 (DOACs), \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8,\u00a0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10d8\u10e1 \u10d0\u10dc\u10d0\u10db\u10dc\u10d4\u10d6\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d0\u10e5\u10d5\u10d7 \u10d0\u10dc\u10e2\u10d8\u10e4\u10dd\u10e1\u10e4\u10dd\u10da\u10d8\u10de\u10d8\u10d3\u10e3\u10e0\u10d8 \u10e1\u10d8\u10dc\u10d3\u10e0\u10dd\u10db\u10d8\u10e1 \u10d3\u10d8\u10d0\u10d2\u10dc\u10dd\u10d6\u10d8. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d0\u10d7\u10d5\u10d8\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d0\u10e5\u10d5\u10d7 \u10d3\u10d0\u10d3\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10e1\u10d0\u10db\u10d8\u10d5\u10d4 \u10e2\u10d8\u10de\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10d6\u10d4 (\u10db\u10d2\u10da\u10e3\u10e0\u10d0\u10e1 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d8, \u10d0\u10dc\u10e2\u10d8\u10d9\u10d0\u10e0\u10d3\u10d8\u10dd\u10da\u10d8\u10de\u10d8\u10dc\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10d1\u10d4\u10e2\u10d0-2-\u10d2\u10da\u10d8\u10d9\u10dd\u10de\u10e0\u10dd\u10e2\u10d4\u10d8\u10dc 1 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10d4\u10d1\u10d8), DOAC-\u10d4\u10d1\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10db\u10dd\u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10d4 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10e3\u10da\u10d8 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da \u10e1\u10d8\u10ee\u10e8\u10d8\u10e0\u10d4\u10e1\u10d7\u10d0\u10dc,\u00a0 K \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d0\u10d2\u10dd\u10dc\u10d8\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7.<\/p>\n<p><strong>\u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 <\/strong><strong>\u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 PCI \u10e1\u10e2\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d3\u10d0\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10d7<\/strong><\/p>\n<p>\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d8\u10dc\u10e2\u10d4\u10e0\u10d5\u10d4\u10dc\u10ea\u10d8\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e4\u10d0\u10e0\u10d2\u10da\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d8\u10e1 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d8 \u10db\u10d8\u10d6\u10d0\u10dc\u10d8 \u10d8\u10e7\u10dd \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d0\u10e5\u10d5\u10d7 \u10d0\u10e0\u10d0\u10e1\u10d0\u10e0\u10e5\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d2\u10e3\u10da\u10d7\u10d0 \u10e4\u10d8\u10d1\u10e0\u10d8\u10da\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10e3\u10e2\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0\u10d7 PCI \u10e1\u10e2\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d7\u10d0\u10d5\u10e1\u10d4\u10d1\u10d8\u10d7. \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d0\u10db \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8\u10d0. \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d0\u10dc\u10d0\u10db\u10dc\u10d4\u10d6\u10e8\u10d8 \u10d0\u10e5\u10d5\u10d7 \u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8\/\u10e2\u10e0\u10d0\u10dc\u10d6\u10d8\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10d8\u10e8\u10d4\u10db\u10d8\u10e3\u10e0\u10d8 \u10e8\u10d4\u10e2\u10d4\u10d5\u10d0\u00a0 (TIA).<\/p>\n<p><strong>PE-\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10f0\u10d4\u10db\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10e3\u10e0\u10d0\u10d3 \u10d0\u10e0\u10d0\u10e1\u10e2\u10d0\u10d1\u10d8\u10da\u10e3\u10e0\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 \u10d0\u10dc \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d4\u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d0\u10d7 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10da\u10d8\u10d6\u10d8 \u10d0\u10dc \u10de\u10e3\u10da\u10db\u10dd\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10d4\u10db\u10d1\u10dd\u10da\u10d4\u10e5\u10e2\u10dd\u10db\u10d8\u10d0 <\/strong><\/p>\n<p>\u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0\u10d0\u10e4\u10e0\u10d0\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10f0\u10d4\u10de\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10d0\u10da\u10e2\u10d4\u10e0\u10dc\u10d0\u10e2\u10d8\u10d5\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d8\u10d7 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e4\u10d8\u10da\u10e2\u10d5\u10d8\u10e1 \u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10f0\u10d4\u10db\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10d0\u10e0\u10d0\u10e1\u10e2\u10d0\u10d1\u10d8\u10da\u10e3\u10e0\u10dc\u10d8 \u10d0\u10e0\u10d8\u10d0\u10dc \u10d0\u10dc \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10e9\u10d0\u10d8\u10e2\u10d0\u10e0\u10dd\u10dc \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10da\u10d8\u10d6\u10d8 \u10d0\u10dc \u10e4\u10d8\u10da\u10e2\u10d5\u10d8\u10e1 \u10d4\u10db\u10d1\u10dd\u10da\u10d4\u10e5\u10e2\u10dd\u10db\u10d8\u10d0, \u10d5\u10d8\u10dc\u10d0\u10d8\u10d3\u10d0\u10dc \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da \u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d3\u10d0\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8\/\u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d0\u10dc\u10d4\u10e1\u10d7\u10d4\u10d6\u10d8\u10d0 \u10d0\u10dc \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0<\/strong><\/p>\n<p>\u10dc\u10d4\u10d8\u10e0\u10d0\u10e5\u10e1\u10d8\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d4\u10e1\u10d7\u10d4\u10d6\u10d8\u10d8\u10e1 (\u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8\/\u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d0\u10dc\u10d4\u10e1\u10d7\u10d4\u10d6\u10d8\u10d0) \u10d0\u10dc \u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8\/\u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d4\u10db\u10d1\u10dd\u10da\u10d8\u10e3\u10e0\u10d8 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1 \u10db\u10d8\u10d6\u10dc\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d4\u10dc \u10d0\u10dc\u10e2\u10d8\u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10e3\u10da\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7, \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d0\u10dc \u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10f0\u10d4\u10db\u10d0\u10e2\u10dd\u10db\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8, \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc \u10db\u10e3\u10d3\u10db\u10d8\u10d5\u10d8 \u10d3\u10d0\u10db\u10d1\u10da\u10d0. \u10d0\u10db \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 \u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1 \u10de\u10dd\u10e1\u10e2\u10dd\u10de\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d0\u10dc \u10f0\u10d4\u10db\u10dd\u10e1\u10e2\u10d0\u10d6\u10d6\u10d4 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1. \u10e0\u10d8\u10e1\u10d9\u10d8 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 \u10e2\u10e0\u10d0\u10d5\u10db\u10e3\u10da\u10d8 \u10d0\u10dc \u10d2\u10d0\u10dc\u10db\u10d4\u10dd\u10e0\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d0\u10dc \u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10d7. \u00a0\u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10ee\u10e8\u10d8\u10e0\u10d8 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10db\u10ee\u10e0\u10d8\u10d5 (\u10db\u10d0\u10d2., \u10e4\u10d4\u10ee\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d1\u10e3\u10df\u10d4\u10d1\u10d0 \u10d0\u10dc \u10e1\u10d8\u10e1\u10e3\u10e1\u10e2\u10d4, \u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc \u10e8\u10d0\u10e0\u10d3\u10d8\u10e1 \u10d1\u10e3\u10e8\u10e2\u10d8\u10e1 \u10d3\u10d8\u10e1\u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0). \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10e1\u10d0\u10e1\u10ec\u10e0\u10d0\u10e4\u10dd \u10d3\u10d8\u10d0\u10d2\u10dc\u10dd\u10e1\u10e2\u10d8\u10d9\u10d0 \u10d3\u10d0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0. \u10dc\u10d4\u10d8\u10e0\u10d0\u10e5\u10e1\u10d8\u10d0\u10da\u10e3\u10e0\u10d8 \u10d8\u10dc\u10e2\u10d4\u10e0\u10d5\u10d4\u10dc\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10ec\u10e7\u10d4\u10d1\u10d0\u10db\u10d3\u10d4 \u10d4\u10e5\u10d8\u10db\u10db\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10d0\u10e4\u10d0\u10e1\u10dd\u10e1 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d8 \u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10d4\u10da\u10d8 \u10d3\u10d0 \u10e0\u10d8\u10e1\u10d9\u10d4\u10d1\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10e1 \u10d0\u10dc \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10db\u10d0\u10ea \u10e3\u10dc\u10d3\u10d0 \u10db\u10d8\u10d8\u10d8\u10e6\u10dd\u10dc \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d0\u10e5\u10e2\u10d8\u10d9\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 20\u10db\u10d2 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10e5\u10e1\u10d8\u10d0\u10da\u10e3\u10e0\u10d8 (\u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8\/\u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8) \u10d0\u10dc\u10d4\u10e1\u10d7\u10d4\u10d6\u10d8\u10d8\u10e1 \u10d0\u10dc \u10e1\u10de\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10da\u10d0\u10d3, \u10d2\u10d0\u10e1\u10d0\u10d7\u10d5\u10d0\u10da\u10d8\u10e1\u10d8\u10ec\u10dc\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10e4\u10d8\u10da\u10d8. \u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10d8\u10e1 \u10e9\u10d0\u10d3\u10d2\u10db\u10d0 \u10d0\u10dc \u10d0\u10db\u10dd\u10e6\u10d4\u10d1\u10d0 \u10d0\u10dc \u10da\u10e3\u10db\u10d1\u10d0\u10da\u10e3\u10e0\u10d8 \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0 \u10e1\u10d0\u10e3\u10d9\u10d4\u10d7\u10d4\u10e1\u10dd\u10d3 \u10ee\u10dd\u10e0\u10ea\u10d8\u10d4\u10da\u10d3\u10d4\u10d1\u10d0 \u10db\u10d0\u10e8\u10d8\u10dc, \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8 \u10d3\u10d0\u10d1\u10d0\u10da\u10d8\u10d0. \u10d7\u10e3\u10db\u10ea\u10d0, \u10d7\u10d8\u10d7\u10dd\u10d4\u10e3\u10da \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10e8\u10d8 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d0\u10d3 \u10d3\u10d0\u10d1\u10d0\u10da\u10d8 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10db\u10d8\u10e6\u10ec\u10d4\u10d5\u10d8\u10e1 \u10d6\u10e3\u10e1\u10e2\u10d8 \u10d3\u10e0\u10dd \u10e3\u10ea\u10dc\u10dd\u10d1\u10d8\u10d0.<\/p>\n<p>\u10d4\u10de\u10d8\u10d3\u10e3\u10e0\u10e3\u10da\u10d8 \u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10d8\u10e1 \u10d0\u10db\u10dd\u10e6\u10d4\u10d1\u10d0\u10db\u10d3\u10d4, \u10d6\u10dd\u10d2\u10d0\u10d3\u10d8 PK \u10db\u10d0\u10ee\u10d0\u10e1\u10d8\u10d0\u10d7\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d1\u10dd\u10da\u10dd \u10e8\u10d4\u10e7\u10d5\u10d0\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10d5\u10d8\u10d3\u10d4\u10e1 \u10db\u10d8\u10dc\u10d8\u10db\u10e3\u10db 2x \u10dc\u10d0\u10ee\u10d4\u10d5\u10d0\u10e0\u10d2\u10d0\u10db\u10dd\u10e7\u10dd\u10e4\u10d8\u10e1 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8, \u10d0\u10dc\u10e3 \u10db\u10d8\u10dc\u10d8\u10db\u10e3\u10db 18 \u10e1\u10d0\u10d0\u10d7\u10d8 \u10d0\u10ee\u10d0\u10da\u10d2\u10d0\u10d6\u10e0\u10d3\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0 26 \u10e1\u10d0\u10d0\u10d7\u10d8 \u10ee\u10d0\u10dc\u10d3\u10d0\u10d6\u10db\u10e3\u10da \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8. \u10d9\u10d0\u10d7\u10d4\u10e2\u10d4\u10e0\u10d8\u10e1 \u10d0\u10db\u10dd\u10e6\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0\u10db\u10d3\u10d4 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10d5\u10d8\u10d3\u10d4\u10e1 \u10db\u10d8\u10dc\u10d8\u10db\u10e3\u10db 6 \u10e1\u10d0\u10d0\u10d7\u10d8.<\/p>\n<p>\u10e2\u10e0\u10d0\u10d5\u10db\u10e3\u10da\u10d8 \u10de\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10d3\u10d0\u10d8\u10d3\u10dd\u10e1 24 \u10e1\u10d0\u10d0\u10d7\u10d8\u10d7.<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8 \u10d8\u10dc\u10d5\u10d0\u10d6\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10d3\u10e3\u10e0\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d8\u10dc \u10d3\u10d0 \u10db\u10d0\u10d7 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2<\/strong><\/p>\n<p>\u10d8\u10dc\u10d5\u10d0\u10d6\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10d3\u10e3\u10e0\u10d8\u10e1 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d8\u10e1 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d4\u10e5\u10d8\u10db\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10d6\u10d4, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d0\u10db\u10d3\u10d4 \u10e1\u10e3\u10da \u10db\u10ea\u10d8\u10e0\u10d4 24 \u10e1\u10d0\u10d0\u10d7\u10d8\u10d7 \u10d0\u10d3\u10e0\u10d4.<\/p>\n<p>\u10d7\u10e3 \u10de\u10e0\u10dd\u10ea\u10d4\u10d3\u10e3\u10e0\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10d3\u10d4\u10d1\u10d0 \u10e8\u10d4\u10e3\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0, \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10d2\u10d0\u10d3\u10d0\u10e3\u10d3\u10d4\u10d1\u10d4\u10da\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d8\u10e1 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da \u10e0\u10d8\u10e1\u10d9\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7.<\/p>\n<p>\u10d8\u10dc\u10d5\u10d0\u10d6\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10d3\u10e3\u10e0\u10d8\u10e1 \u10d0\u10dc \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d8\u10e1 \u10d3\u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10d7\u10e3 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10f0\u10d4\u10db\u10dd\u10e1\u10e2\u10d0\u10d6\u10d8 \u10dc\u10dd\u10e0\u10db\u10d8\u10e1 \u10e4\u10d0\u10e0\u10d2\u10da\u10d4\u10d1\u10e8\u10d8\u10d0, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10d0\u10ee\u10da\u10d3\u10d4\u10e1 \u10db\u10d0\u10e5\u10e1\u10d8\u10db\u10d0\u10da\u10e3\u10e0\u10d0\u10d3 \u10db\u10dd\u10d9\u10da\u10d4 \u10d3\u10e0\u10dd\u10e8\u10d8.<\/p>\n<p><strong>\u10ee\u10d0\u10dc\u10d3\u10d0\u10d6\u10db\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10db\u10d0\u10e2\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8.<\/p>\n<p><strong>\u10d3\u10d4\u10e0\u10db\u10d0\u10e2\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10e1\u10d4\u10e0\u10d8\u10dd\u10d6\u10e3\u10da\u10d8 \u10d9\u10d0\u10dc\u10d8\u10e1 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1, \u10e1\u10e2\u10d8\u10d5\u10d4\u10dc\u10e1-\u10ef\u10dd\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10e1\u10d8\u10dc\u10d3\u10e0\u10dd\u10db\u10d8 \/ \u10e2\u10dd\u10e5\u10e1\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10de\u10d8\u10d3\u10d4\u10e0\u10db\u10e3\u10da\u10d8 \u10dc\u10d4\u10d9\u10e0\u10dd\u10da\u10d8\u10d6\u10d8 \u10d3\u10d0 DRESS \u10e1\u10d8\u10dc\u10d3\u10e0\u10dd\u10db\u10d8, \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10de\u10dd\u10e1\u10e2-\u10db\u10d0\u10e0\u10d9\u10d4\u10e2\u10d8\u10dc\u10d2\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10d8\u10d7. \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1 \u10d4\u10e2\u10d0\u10de\u10d6\u10d4:\u00a0 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d0 \u10e3\u10db\u10d4\u10e2\u10d4\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8 \u10d8\u10ec\u10e7\u10d4\u10d1\u10d0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10de\u10d8\u10e0\u10d5\u10d4\u10da \u10d9\u10d5\u10d8\u10e0\u10d4\u10d1\u10e8\u10d8. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1 \u10d9\u10d0\u10dc\u10d6\u10d4 \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10dc\u10d0\u10e7\u10d0\u10e0\u10d8\u10e1 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1, \u10d8\u10dc\u10e2\u10d4\u10dc\u10e1\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\/\u10d0\u10dc \u10d1\u10e3\u10e8\u10e2\u10e3\u10d9\u10d4\u10d1\u10d8\u10e1), \u10da\u10dd\u10e0\u10ec\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10e0\u10e1\u10d8\u10e1 \u10d2\u10d0\u10e6\u10d8\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc \u10f0\u10d8\u10de\u10d4\u10e0\u10db\u10d2\u10e0\u10eb\u10dc\u10dd\u10d1\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d8\u10e1\u10d7\u10d0\u10dc\u10d0\u10d5\u10d4.<\/p>\n<p><strong>\u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d7\u10d0\u10dc <\/strong><\/p>\n<p><u>CYP3A4 \u10d3\u10d0 P-gp \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8<\/u><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d0 \u10d9\u10d4\u10e2\u10dd\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8\u10e1 (400 \u10db\u10d2 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da \u10d3\u10e6\u10d4\u10e8\u10d8) \u10d0\u10dc \u10e0\u10d8\u10e2\u10dd\u10dc\u10d0\u10d5\u10d8\u10e0\u10d8\u10e1 (600 \u10db\u10d2 \u10dd\u10e0\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8) \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d0\u10d3 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10db \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC -\u10d8\u10e1 2.6\/2.5-\u10ef\u10d4\u10e0 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 Cmax-\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d8\u10e1 1.6-\u10ef\u10d4\u10e0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10d0, \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d7\u10d0\u10dc\u10db\u10ee\u10da\u10d4\u10d1\u10d8 \u10d2\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10d7, \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8. \u10d0\u10db\u10d8\u10e2\u10dd\u10db, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d0\u10d3 \u10d2\u10d0\u10d3\u10d8\u10d0\u10dc\u00a0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1 \u10d0\u10d6\u10dd\u10da\u10d8\u10e1 \u10ef\u10d2\u10e3\u10e4\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10e2\u10d8\u10db\u10d8\u10d9\u10dd\u10d6\u10e3\u10e0\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10d9\u10d4\u10e2\u10dd\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8, \u10d8\u10e2\u10e0\u10d0\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8, \u10d5\u10dd\u10e0\u10d8\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8 \u10d3\u10d0 \u10de\u10dd\u10d6\u10d0\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8 \u10d0\u10dc \u10d0\u10d8\u10d5 \u10de\u10e0\u10dd\u10e2\u10d4\u10d0\u10d6\u10d0\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8. \u00a0\u10d4\u10e1 \u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea CYP3A4, \u10d0\u10e1\u10d4\u10d5\u10d4 P-gp \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8.<\/p>\n<p>\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10eb\u10da\u10d8\u10d4\u10e0 \u10d0\u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e0\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d4\u10da\u10d8\u10db\u10d8\u10dc\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10d4\u10e0\u10d7 \u10d2\u10d6\u10d0\u10e1, CYP3A4-\u10e1 \u10d0\u10dc P-gp-\u10e1,\u00a0 \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd\u10d3, \u10e3\u10e4\u10e0\u10dd \u10dc\u10d0\u10d9\u10da\u10d4\u10d1\u10d8 \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10d8\u10d7 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10d0\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e8\u10d8. \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10d9\u10da\u10d0\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10db\u10d0 (500 \u10db\u10d2 \u10dd\u10e0\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8), \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10eb\u10da\u10d8\u10d4\u10e0\u10d0\u10d3 \u10d7\u10e0\u10d2\u10e3\u10dc\u10d0\u10d5\u10e1 CYP3A4 \u10d8\u10d6\u10dd\u10e4\u10d4\u10e0\u10db\u10d4\u10dc\u10e2\u10e1 \u10d3\u10d0 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 P-gp-\u10e1, \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC-\u10d8\u10e1 1,5-\u10ef\u10d4\u10e0 \u10d3\u10d0 Cmax-\u10d8\u10e1 1,4-\u10ef\u10d4\u10e0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10d0. \u10d9\u10da\u10d0\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d7\u10d0\u10dc \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd\u10d3 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e3\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10e1\u10dd\u10d1\u10d0\u10e8\u10d8, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1:.<\/p>\n<p>\u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d8 (500\u10db\u10d2 \u10e1\u10d0\u10db\u10ef\u10d4\u10e0 \u10d3\u10e6\u10d4\u10e8\u10d8), \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 \u10d0\u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e0\u10d4\u10d1\u10e1 CYP3A4-\u10e1 \u10d3\u10d0 P-gp-\u10e1, \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC-\u10d8\u10e1\u10d0 \u10d3\u10d0 Cmax-\u10d8\u10e1 1.3-\u10ef\u10d4\u10e0 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d0. \u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d7\u10d0\u10dc \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd\u10d3 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e3\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10e1\u10dd\u10d1\u10d0\u10e8\u10d8, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8.<\/p>\n<p>\u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d8 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d8 (500 \u10db\u10d2 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10e1\u10d0\u10db\u10ef\u10d4\u10e0) \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC-\u10d8\u10e1 1.8-\u10ef\u10d4\u10e0 \u10d3\u10d0 Cmax-\u10d8\u10e1 1.6-\u10ef\u10d4\u10e0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10d0\u10e1, \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10dc\u10dd\u10e0\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7. \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d8 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC-\u10d8\u10e1 2.0-\u10ef\u10d4\u10e0 \u10d3\u10d0 Cmax-\u10d8\u10e1 1.6-\u10ef\u10d4\u10e0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10d0\u10e1, \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10dc\u10dd\u10e0\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7. \u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10db\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e3\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10dd\u10d1\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e1.<\/p>\n<p>\u10e4\u10da\u10e3\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d8 (400 \u10db\u10d2 \u10d3\u10e6\u10d4\u10e8\u10d8 \u10d4\u10e0\u10d7\u10ee\u10d4\u10da), CYP 3A4 \u10d8\u10d6\u10dd\u10e4\u10d4\u10e0\u10db\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d8, \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 AUC-\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d8\u10e1 1.4-\u10ef\u10d4\u10e0 \u10d3\u10d0 Cmax-\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d8\u10e1 1,3-\u10ef\u10d4\u10e0 \u10d6\u10e0\u10d3\u10d0\u10e1. \u10e4\u10da\u10e3\u10d9\u10dd\u10dc\u10d0\u10d6\u10dd\u10da\u10d7\u10d0\u10dc \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10e1\u10d0\u10d5\u10d0\u10e0\u10d0\u10e3\u10d3\u10dd\u10d3 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e3\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10e1\u10dd\u10d1\u10d0\u10e8\u10d8, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8.<\/p>\n<p>\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d3\u10e0\u10dd\u10dc\u10d4\u10d3\u10d0\u10e0\u10dd\u10dc\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0.<\/p>\n<p><u>\u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8<\/u><\/p>\n<p>\u10d4\u10dc\u10dd\u10e5\u10e1\u10d0\u10de\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1\u10d0 (\u10d4\u10e0\u10d7\u10ef\u10d4\u10e0\u10d0\u10d3\u10d8 \u10d3\u10dd\u10d6\u10d0 40\u10db\u10d2) \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 (\u10d4\u10e0\u10d7\u10ef\u10d4\u10e0\u10d0\u10d3\u10d8 \u10d3\u10dd\u10d6\u10d0 10\u10db\u10d2) \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10d5\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d0\u10dc\u10e2\u10d8-Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d7\u10d0\u10dc \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10d4\u10d1\u10d0\u10e8\u10d8 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10d0\u10d3\u10d8\u10e2\u10d8\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8, \u10e0\u10d0\u10e1\u10d0\u10ea \u10d0\u10e0 \u10d0\u10ee\u10da\u10d3\u10d0 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10d0\u10e0\u10d0\u10db\u10d4\u10e2\u10e0\u10d4\u10d1\u10d6\u10d4 (PT, aPTT). \u00a0\u10d4\u10dc\u10dd\u10e5\u10e1\u10d0\u10de\u10d0\u10e0\u10d8\u10dc\u10d8 \u10d0\u10e0 \u10ea\u10d5\u10da\u10d8\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10d0\u10e1. \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd, \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e9\u10d4\u10dc\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3.<\/p>\n<p><u>\u10d0\u10e0\u10d0\u10e1\u10e2\u10d4\u10e0\u10dd\u10d8\u10d3\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 (NSAID)\/\u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d2\u10e0\u10d4\u10d2\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8<\/u><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 (15\u10db\u10d2) \u10d3\u10d0 \u10dc\u10d0\u10de\u10e0\u10dd\u10e5\u10e1\u10d4\u10dc\u10d8\u10e1 (500\u10db\u10d2) \u10d4\u10e0\u10d7\u10d0\u10d3 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d3\u10e0\u10dd\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d0. \u10db\u10d8\u10e3\u10ee\u10d4\u10d3\u10d0\u10d5\u10d0\u10d3 \u10d0\u10db\u10d8\u10e1\u10d0, \u10ea\u10d0\u10da\u10d9\u10d4\u10e3\u10da \u10de\u10d8\u10e0\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e3\u10e4\u10e0\u10dd \u10d2\u10d0\u10db\u10dd\u10ee\u10d0\u10e2\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8.<\/p>\n<p>\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10dc \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d0\u10e0 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 500 \u10db\u10d2 \u10d0\u10ea\u10d4\u10e2\u10d8\u10da\u10e1\u10d0\u10da\u10d8\u10ea\u10d8\u10da\u10d8\u10e1 \u10db\u10df\u10d0\u10d5\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3.<\/p>\n<p>\u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d8\u10da\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1\u10d0 (15\u10db\u10d2) \u10d3\u10d0 \u10d9\u10da\u10dd\u10de\u10d8\u10d3\u10dd\u10d2\u10e0\u10d4\u10da\u10e1 (\u10d3\u10d0\u10db\u10e2\u10d5\u10d8\u10e0\u10d7\u10d5\u10d4\u10da\u10d8 \u10d3\u10dd\u10d6\u10d0 300\u10db\u10d2 \u10e8\u10d4\u10db\u10d0\u10dc\u10d0\u10e0\u10e9\u10e3\u10dc\u10d4\u10d1\u10d4\u10da\u10d8 \u10d3\u10dd\u10d6\u10d8\u10e1 75\u10db\u10d2 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10d5\u10dc\u10d8\u10d7) \u10e8\u10dd\u10e0\u10d8\u10e1, \u10d7\u10e3\u10db\u10ea\u10d0, \u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10e8\u10d8 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d3\u10e0\u10dd\u10d8\u10e1 \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d4\u10d1\u10d0, \u10e0\u10d0\u10ea \u10d0\u10e0 \u10d9\u10dd\u10e0\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d3\u10d0 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d2\u10e0\u10d4\u10d2\u10d0\u10ea\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0 P- \u10e1\u10d4\u10da\u10d4\u10e5\u10e2\u10d8\u10dc\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4\u10e1\u10d7\u10d0\u10dc \u10d0\u10dc GPIIb\/IIIa \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4\u10e1\u10d7\u10d0\u10dc.<\/p>\n<p>\u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d4\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd, \u10d7\u10e3 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d4\u10dc \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10d0\u10e0\u10d0\u10e1\u10e2\u10d4\u10e0\u10dd\u10d8\u10d3\u10e3\u10da\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10d7 (\u10d0\u10ea\u10d4\u10e2\u10d8\u10da\u10e1\u10d0\u10da\u10d8\u10ea\u10d8\u10da\u10d8\u10e1 \u10db\u10df\u10d0\u10d5\u10d0\u10e1 \u10e9\u10d0\u10d7\u10d5\u10da\u10d8\u10d7) \u10d3\u10d0 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d2\u10e0\u10d4\u10d2\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10d7, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10d4\u10e1 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10ec\u10d4\u10e1\u10d8, \u10d6\u10e0\u10d3\u10d8\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10e1.<\/p>\n<p><u>\u10e1\u10d4\u10e0\u10dd\u10e2\u10dd\u10dc\u10d8\u10dc\u10d8\u10e1 \u10e3\u10d9\u10e3\u10db\u10d8\u10e2\u10d0\u10ea\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e0\u10e9\u10d4\u10d5\u10d8\u10d7\u10d8 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 (SSRI)\/\u10e1\u10d4\u10e0\u10dd\u10e2\u10dd\u10dc\u10d8\u10dc\u10d8-\u10dc\u10dd\u10e0\u10d4\u10de\u10d8\u10dc\u10d4\u10e4\u10e0\u10d8\u10dc\u10d8\u10e1 \u10e3\u10d9\u10e3\u10db\u10d8\u10e2\u10d0\u10ea\u10d4\u10d1\u10d8\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 (SNRI)<\/u><\/p>\n<p>\u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d0\u10d3, \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d3\u10d4\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 SSRI-\u10d4\u10d1\u10d7\u10d0\u10dc \u10d0\u10dc SNRI-\u10d4\u10d1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d6\u10d4 \u10db\u10d0\u10d7\u10d8 \u10d6\u10d4\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10de\u10e0\u10dd\u10d2\u10e0\u10d0\u10db\u10d0\u10e8\u10d8 \u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e7\u10d5\u10d4\u10da\u10d0 \u10ef\u10d2\u10e3\u10e4\u10e8\u10d8 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10d0\u10dc \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10e0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e1\u10d8\u10ee\u10e8\u10d8\u10e0\u10d4.<\/p>\n<p><u>\u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d8<\/u><\/p>\n<p>K \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d0\u10d2\u10dd\u10dc\u10d8\u10e1\u10e2\u10d8 \u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d8\u10d3\u10d0\u10dc (INR 2.0-3.0) \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d6\u10d4 (20\u10db\u10d2) \u10d0\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d3\u10d0\u10dc (20\u10db\u10d2) \u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d6\u10d4 (INR 2.0-3.0) \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1\u10d0\u10e1 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0 \u10de\u10e0\u10dd\u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10d8\u10e1 \u10d3\u10e0\u10dd\/INR (\u10dc\u10d4\u10dd\u10de\u10da\u10d0\u10e1\u10e2\u10d8\u10dc\u10d8) \u10e3\u10e4\u10e0\u10dd \u10d3\u10d8\u10d3\u10d8 \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10d8\u10d7 \u10d5\u10d8\u10d3\u10e0\u10d4 \u10d4\u10e1 \u10db\u10dd\u10e1\u10d0\u10da\u10dd\u10d3\u10dc\u10d4\u10da\u10d8 \u10d8\u10e7\u10dd \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10d0\u10e0\u10e2\u10d8\u10d5\u10d8 \u10d3\u10d0\u10ef\u10d0\u10db\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 (INR \u2013\u10e1 \u10ea\u10d0\u10da\u10d9\u10d4\u10e3\u10da\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d0\u10e6\u10ec\u10d4\u10d5\u10d3\u10d4\u10e1 12-\u10e1), \u10ee\u10dd\u10da\u10dd aPTT\u2013\u10d6\u10d4 \u10d6\u10d4\u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0, Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10d8\u10e1 \u10d4\u10dc\u10d3\u10dd\u10d2\u10d4\u10dc\u10e3\u10e0\u10d8 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10d0\u10da\u10d8\u10e1 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d0 \u10d8\u10e7\u10dd \u10d0\u10d3\u10d8\u10e2\u10d8\u10e3\u10e0\u10d8.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10e1 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d2\u10d0\u10e0\u10d3\u10d0\u10db\u10d0\u10d5\u10d0\u10da\u10d8 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8, \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8 \u10e2\u10d4\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d8\u10d7, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d6\u10d4\u10ea \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10e1 \u10d0\u10e0 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d8, \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0\u10e1 Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1, PiCT \u10d3\u10d0 HepTest\u2013\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0. \u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10d1\u10dd\u10da\u10dd \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10db\u10d4\u10dd\u10d7\u10ee\u10d4 \u10d3\u10e6\u10d4\u10e1, \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d4\u10d1\u10d8\u10e1 \u10e7\u10d5\u10d4\u10da\u10d0 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 (\u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 PT, aPTT, Xa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e0\u10d4\u10d1\u10d0 \u10d3\u10d0 ETP) \u10d0\u10e1\u10d0\u10ee\u10d0\u10d5\u10d3\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e1.<\/p>\n<p>\u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10e1 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d2\u10d0\u10e0\u10d3\u10d0\u10db\u10d0\u10d5\u10d0\u10da\u10d8 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0\u10e1 INR \u2013\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 Ctrough\u00a0 \u10e4\u10dd\u10dc\u10d6\u10d4 (\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc 24\u10e1\u10d0\u10d0\u10d7\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2), \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10d0\u10db \u10db\u10dd\u10db\u10d4\u10dc\u10e2\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1 \u10d0\u10e5\u10d5\u10e1 \u10db\u10d8\u10dc\u10d8\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10d0\u10db \u10e2\u10d4\u10e1\u10e2\u10d6\u10d4.<\/p>\n<p>\u10d5\u10d0\u10e0\u10e4\u10d0\u10e0\u10d8\u10dc\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d0.<\/p>\n<p><u>CYP3A4-\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8<\/u><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0\u00a0 CYP3A4-\u10d8\u10e1 \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10d8\u10dc\u10d3\u10e3\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1, \u10e0\u10d8\u10e4\u10d0\u10db\u10de\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1, \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d3\u10d0\u10dc\u10d8\u10e8\u10d5\u10dc\u10d0\u10db \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd AUC\u2013\u10d8\u10e1 \u10d3\u10d0\u10d0\u10ee\u10da\u10dd\u10d4\u10d1\u10d8\u10d7 50%-\u10d8\u10d7 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0, \u10db\u10d8\u10e1\u10d8 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8\u10e1 \u10de\u10d0\u10e0\u10d0\u10da\u10d4\u10da\u10e3\u10e0\u10d8 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d8\u10d7. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10db CYP3A4-\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10eb\u10da\u10d8\u10d4\u10e0 \u10d8\u10dc\u10d3\u10e3\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d7\u10d0\u10dc (\u10db\u10d0\u10d2., \u10e4\u10d4\u10dc\u10d8\u10e2\u10dd\u10d8\u10dc\u10d7\u10d0\u10dc, \u10d9\u10d0\u10e0\u10d1\u10d0\u10db\u10d0\u10d6\u10d4\u10de\u10d8\u10dc\u10d7\u10d0\u10dc, \u10e4\u10d4\u10dc\u10dd\u10d1\u10d0\u10e0\u10d1\u10d8\u10e2\u10d0\u10da\u10d7\u10d0\u10dc \u10d0\u10dc \u10d9\u10e0\u10d0\u10d6\u10d0\u10dc\u10d0\u10e1\u10d7\u10d0\u10dc\u00a0 (Hypericum perforatum)) \u10d4\u10e0\u10d7\u10d0\u10d3, \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0. \u10d0\u10db\u10d8\u10e2\u10dd\u10db, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10d3\u10d0\u10d8\u10dc\u10d8\u10e8\u10dc\u10dd\u10e1 CYP3A4-\u10d8\u10e1 \u10eb\u10da\u10d8\u10d4\u10e0 \u10d8\u10dc\u10d3\u10e3\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3, \u10e1\u10d0\u10dc\u10d0\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8 \u10e7\u10e3\u10e0\u10d0\u10d3\u10e6\u10d4\u10d1\u10d8\u10d7 \u10d0\u10e0 \u10d8\u10e5\u10dc\u10d4\u10d1\u10d0 \u10e8\u10d4\u10db\u10dd\u10ec\u10db\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10d6\u10d8\u10e1 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d0\u10d6\u10d4.<\/p>\n<p><strong>\u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d4\u10d1\u10d8<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10d8\u10d7 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8. \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8 \u10ea\u10ee\u10d5\u10d8\u10e0\u10d8\u10d3\u10d0\u10dc\u00a0 (4.5%) \u10d3\u10d0 \u10d9\u10e3\u10ed-\u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10e1 \u10e2\u10e0\u10d0\u10e5\u10e2\u10d8\u10d3\u10d0\u10dc (3.8%).<\/p>\n<p><u>\u10ea\u10d0\u10da\u10d9\u10d4\u10e3\u10da\u10d8 \u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10ec\u10d4\u10e0\u10d0<\/u><\/p>\n<p>\u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10dc\u10d4\u10d1\u10d8\u10e1\u10db\u10d8\u10d4\u10e0\u10d8 \u10e5\u10e1\u10dd\u10d5\u10d8\u10da\u10d8\u10d3\u10d0\u10dc \u10d0\u10dc \u10dd\u10e0\u10d2\u10d0\u10dc\u10dd\u10d3\u10d0\u10dc \u10e4\u10d0\u10e0\u10e3\u10da\u10d8 \u10d0\u10dc \u10d0\u10e8\u10d9\u10d0\u10e0\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da \u10e0\u10d8\u10e1\u10d9\u10d7\u10d0\u10dc, \u10e0\u10d0\u10db\u10d0\u10ea \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10de\u10dd\u10e1\u10e2\u10f0\u10d4\u10db\u10dd\u10e0\u10d0\u10d2\u10d8\u10e3\u10da\u10d8 \u10d0\u10dc\u10d4\u10db\u10d8\u10d0. \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8, \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d4 (\u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e4\u10d0\u10e2\u10d0\u10da\u10e3\u10e0\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8) \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d0\u10dc\u10d4\u10db\u10d8\u10d8\u10e1\u10d0 \u10d3\u10d0\/\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1\u00a0 \u10da\u10dd\u10d9\u10d0\u10da\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1\u10d0\u00a0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10e8\u10e2\u10d0\u10d1\u10d8\u10e1\u00a0 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7. \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8 \u10da\u10dd\u10e0\u10ec\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10e0\u10e1\u10d8\u10d3\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8 (\u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10ea\u10ee\u10d5\u10d8\u10e0\u10d8\u10d3\u10d0\u10dc, \u10e6\u10e0\u10eb\u10d8\u10da\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc, \u10d9\u10e3\u10ed-\u10dc\u10d0\u10ec\u10da\u10d0\u10d5\u10d8\u10d3\u10d0\u10dc, \u10e8\u10d0\u10e0\u10d3-\u10e1\u10d0\u10e1\u10e5\u10d4\u10e1\u10dd \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10d3\u10d0\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d5\u10d0\u10d2\u10d8\u10dc\u10d0\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d4\u10dc\u10e1\u10e2\u10e0\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d4\u10d1\u10d8) \u10d3\u10d0 \u10d0\u10dc\u10d4\u10db\u10d8\u10d0 \u10e3\u10e4\u10e0\u10dd \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1\u10d0\u10e1 VKA-\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7. \u10d0\u10db\u10e0\u10d8\u10d2\u10d0\u10d3, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d3\u10d0, \u10e4\u10d0\u10e0\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e1\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10d3 \u10d3\u10d0 \u10d0\u10e8\u10d9\u10d0\u10e0\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10e4\u10d0\u10e1\u10d4\u10d1\u10da\u10d0\u10d3 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10e6\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10f0\u10d4\u10db\u10dd\u10d2\u10da\u10dd\u10d1\u10d8\u10dc\u10d8\u10e1\/\u10f0\u10d4\u10db\u10d0\u10e2\u10dd\u10d9\u10e0\u10d8\u10e2\u10d8\u10e1 \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8. \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da \u10ef\u10d2\u10e3\u10e4\u10d4\u10d1\u10e8\u10d8, \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0\u10ea \u10d0\u10e6\u10d4\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0\u10d7 \u10d0\u10e0\u10d0\u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10d3\u10d8 \u10db\u10eb\u10d8\u10db\u10d4 \u10d0\u10e0\u10e2\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10f0\u10d8\u10de\u10d4\u10e0\u10e2\u10d4\u10dc\u10d6\u10d8\u10d0 \u10d3\u10d0\/\u10d0\u10dc \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10f0\u10d4\u10db\u10dd\u10e1\u10e2\u10d0\u10d6\u10d6\u10d4 \u10db\u10dd\u10e5\u10db\u10d4\u10d3 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10e1. \u10db\u10d4\u10dc\u10e1\u10e2\u10e0\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d3\u10d4\u10e1 \u10d3\u10d0\/\u10d0\u10dc \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d3\u10d4\u10e1. \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d0\u10e6\u10d8\u10dc\u10d8\u10e8\u10dc\u10dd\u10e1 \u10f0\u10d4\u10db\u10dd\u10e0\u10d0\u10d2\u10d8\u10e3\u10da\u10d8 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10e1\u10d8\u10e1\u10e3\u10e1\u10e2\u10d4, \u10e1\u10d8\u10e4\u10d4\u10e0\u10db\u10d9\u10d7\u10d0\u10da\u10d4, \u10d7\u10d0\u10d5\u10d1\u10e0\u10e3\u10e1\u10ee\u10d5\u10d4\u10d5\u10d0, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d9\u10d8\u10d5\u10d8\u10da\u10d8 \u10d0\u10dc \u10d0\u10e3\u10ee\u10e1\u10dc\u10d4\u10da\u10d8 \u10e8\u10d4\u10e8\u10e3\u10de\u10d4\u10d1\u10d0, \u10d3\u10d8\u10e1\u10de\u10dc\u10dd\u10d4 \u10d3\u10d0 \u10d0\u10e3\u10ee\u10e1\u10dc\u10d4\u10da\u10d8 \u10e8\u10dd\u10d9\u10e3\u10e0\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0.\u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d0\u10dc\u10d4\u10db\u10d8\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd, \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0 \u10db\u10d8\u10dd\u10d9\u10d0\u10e0\u10d3\u10d8\u10e3\u10db\u10d8\u10e1 \u10d8\u10e8\u10d4\u10db\u10d8\u10d8\u10e1 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10e2\u10d9\u10d8\u10d5\u10d8\u10da\u10d8 \u10d2\u10e3\u10da\u10db\u10d9\u10d4\u10e0\u10d3\u10d8\u10e1 \u10d0\u10e0\u10d4\u10e8\u10d8 \u10d0\u10dc \u10e1\u10e2\u10d4\u10dc\u10dd\u10d9\u10d0\u10e0\u10d3\u10d8\u10d0.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10db\u10d4\u10dd\u10e0\u10d0\u10d3\u10d0\u10d3 \u10db\u10eb\u10d8\u10db\u10d4 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d0\u10e1\u10d7\u10d0\u10dc \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10d4\u10d1\u10d8\u10d7, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10e8\u10d4\u10d9\u10e3\u10db\u10e8\u10d5\u10d8\u10e1 \u10e1\u10d8\u10dc\u10d3\u10e0\u10dd\u10db\u10d8 \u10d3\u10d0 \u10d7\u10d8\u10e0\u10d9\u10db\u10da\u10d8\u10e1 \u10e3\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10dd\u10d1\u10d0 \u10f0\u10d8\u10de\u10dd\u10de\u10d4\u10e0\u10e4\u10e3\u10d6\u10d8\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd. \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10e3\u10e0\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d2\u10d0\u10e1\u10d0\u10d7\u10d5\u10d0\u10da\u10d8\u10e1\u10ec\u10d8\u10dc\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d0\u10da\u10d1\u10d0\u10d7\u10dd\u10d1\u10d0 \u10d7\u10d8\u10d7\u10dd\u10d4\u10e3\u10da\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1.<\/p>\n<p><strong>\u10dd\u10e0\u10e1\u10e3\u10da\u10dd\u10d1\u10d0, \u10da\u10d0\u10e5\u10e2\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0<\/strong> <strong>\u10e4\u10d4\u10e0\u10e2\u10d8\u10da\u10dd\u10d1\u10d0<\/strong><\/p>\n<p><strong><u>\u10dd\u10e0\u10e1\u10e3\u10da\u10dd\u10d1\u10d0<\/u><\/strong><\/p>\n<p>\u10dd\u10e0\u10e1\u10e3\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1. \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10d4\u10d1\u10d6\u10d4 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10db\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10db\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0 \u10e0\u10d4\u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10e2\u10dd\u10e5\u10e1\u10d8\u10d9\u10e3\u10e0\u10dd\u10d1\u10d0. \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d4\u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10e2\u10dd\u10e5\u10e1\u10d8\u10d9\u10e3\u10e0\u10dd\u10d1\u10d8\u10e1, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10de\u10da\u10d0\u10ea\u10d4\u10dc\u10e2\u10d0\u10e8\u10d8 \u10d2\u10d0\u10d3\u10d0\u10e1\u10d5\u10da\u10d8\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10e3\u10d9\u10e3\u10dc\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10d0 \u10dd\u10e0\u10e1\u10e3\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1. \u10e0\u10d4\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10e8\u10d8 \u10e0\u10d4\u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10ea\u10d8\u10e3\u10da\u10d8 \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10e5\u10d0\u10da\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d3\u10d0\u10dd\u10e0\u10e1\u10e3\u10da\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d4\u10d1\u10e3\u10da\u10d8.<\/p>\n<p><strong><u>\u10da\u10d0\u10e5\u10e2\u10d0\u10ea\u10d8\u10d0<\/u><\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10db\u10d4\u10eb\u10e3\u10eb\u10e3\u10e0 \u10d3\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0\u10d3\u10d2\u10d4\u10dc\u10d8\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1. \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10d4\u10d1\u10d6\u10d4 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10dd\u10e4\u10d0 \u10e0\u10eb\u10d4\u10e8\u10d8. \u10d0\u10e5\u10d4\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10e3\u10d9\u10e3\u10dc\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10d0 \u10da\u10d0\u10e5\u10e2\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1. \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10da\u10d4\u10d1\u10d0 \u10eb\u10e3\u10eb\u10e3\u10d7\u10d8 \u10d9\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10e1 \u10d0\u10dc \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10e1\/\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1\u10d2\u10d0\u10dc \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e8\u10d4\u10d9\u10d0\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1.<\/p>\n<p><strong><u>\u10e4\u10d4\u10e0\u10e2\u10d8\u10da\u10dd\u10d1\u10d0<\/u><\/strong><\/p>\n<p>\u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d4\u10e0\u10e2\u10d8\u10da\u10dd\u10d1\u10d0\u10d6\u10d4 \u10d6\u10d4\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10d3\u10d2\u10d4\u10dc\u10d0\u10d3 \u10d0\u10e0 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d0. \u10d3\u10d4\u10d3\u10d0\u10da \u10d3\u10d0 \u10db\u10d0\u10db\u10d0\u10da \u10d5\u10d8\u10e0\u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10d6\u10d4 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10e4\u10d4\u10e0\u10e2\u10d8\u10da\u10dd\u10d1\u10d0\u10d6\u10d4 \u10d6\u10d4\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d0.<\/p>\n<p><strong>\u10d3\u10dd\u10d6\u10d8\u10e1\u00a0 \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10d0<\/strong><\/p>\n<p>\u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d8\u10e8\u10d5\u10d8\u10d0\u10d7\u10d8 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8 1,960 \u10db\u10d2-\u10db\u10d3\u10d4 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1. \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1\u00a0 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u00a0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d0\u10dc \u10e1\u10ee\u10d5\u10d0 \u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd. \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8\u10d0 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10d8\u10d7. \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8 \u10d0\u10d1\u10e1\u10dd\u10e0\u10d1\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 50\u10db\u10d2 \u10d0\u10dc \u10db\u10d4\u10e2\u10d8 \u10e1\u10e3\u10de\u10e0\u10d0\u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10dd\u10e1\u10d0\u10da\u10dd\u10d3\u10dc\u10d4\u10da\u10d8\u10d0 \u10db\u10d0\u10e5\u10e1\u10d8\u10db\u10d0\u10da\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10dd \u10de\u10da\u10d0\u10d6\u10db\u10e3\u10e0\u10d8 \u10d4\u10e5\u10e1\u10de\u10dd\u10d6\u10d8\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db\u10d8 \u10d6\u10e0\u10d3\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d4\u10e8\u10d4, \u10d7\u10e3\u10db\u10ea\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8 \u10e1\u10e3\u10de\u10e0\u10d0\u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10d3\u10dd\u10d6\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1.<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10e1\u10de\u10d4\u10ea\u10d8\u10e4\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d5\u10d4\u10e0\u10e1\u10e3\u10da\u10d8 \u10d0\u10d2\u10d4\u10dc\u10e2\u10d8 (\u10d0\u10dc\u10d3\u10d4\u10e5\u10e1\u10d0\u10dc\u10d4\u10e2 \u10d0\u10da\u10e4\u10d0 (andexanet alfa)), \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8 (\u10d8\u10ee\u10d8\u10da\u10d4\u10d7 \u10d0\u10dc\u10d3\u10d4\u10e5\u10e1\u10d0\u10dc\u10d4\u10e2 \u10d0\u10da\u10e4\u10d0\u10e1 \u201e\u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10e2\u10d8\u10e1 \u10db\u10d0\u10ee\u10d0\u10e1\u10d8\u10d0\u10d7\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10ef\u10d0\u10db\u10d4\u10d1\u10d4\u10da\u10d8 \u10d0\u10dc\u10d2\u10d0\u10e0\u10d8\u10e8\u10d8\u201c).<\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d0\u10d1\u10e1\u10dd\u10e0\u10d1\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10da\u10d0\u10d3 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10dc\u10ee\u10d8\u10da\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d0\u10ee\u10e8\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0.<\/p>\n<p><strong>\u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10db\u10d0\u10e0\u10d7\u10d5\u10d0<\/strong><\/p>\n<p>\u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10e9\u10d4\u10e0\u10d3\u10d4\u10e1 \u10d0\u10dc, \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d3\u10d4\u10e1. \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10dc\u10d0\u10ee\u10d4\u10d5\u10d0\u10e0\u10d2\u10d0\u10db\u10dd\u10e7\u10dd\u10e4\u10d8\u10e1 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8 \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10d3\u10d0\u10d0\u10ee\u10da\u10dd\u10d4\u10d1\u10d8\u10d7 5- 13 \u10e1\u10d0\u10d0\u10d7\u10e1. \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8 \u10dc\u10d0\u10ee\u10d4\u10d5\u10d0\u10e0\u10d2\u10d0\u10db\u10dd\u10e7\u10dd\u10e4\u10d8\u10e1 \u10de\u10d4\u10e0\u10d8\u10dd\u10d3\u10d8,\u00a0 \u10de\u10dd\u10de\u10e3\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d9\u10d8\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 (popPK) \u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10d7, \u10e3\u10e4\u10e0\u10dd \u10dc\u10d0\u10d9\u10da\u10d4\u10d1\u10d8\u10d0. \u10db\u10d0\u10e0\u10d7\u10d5\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d8\u10e7\u10dd\u10e1 \u10d8\u10dc\u10d3\u10d8\u10d5\u10d8\u10d3\u10e3\u10d0\u10da\u10e3\u10e0\u10d8, \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10da\u10dd\u10d9\u10d0\u10da\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7. \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0\u10e1 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d0\u10e2\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10de\u10e0\u10d4\u10e1\u10d8\u10d0 (\u10db\u10d0\u10d2., \u10db\u10eb\u10d8\u10db\u10d4 \u10d4\u10de\u10d8\u10e1\u10e2\u10d0\u10e5\u10e1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1), \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10f0\u10d4\u10db\u10dd\u10e1\u10e2\u10d0\u10d6\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8\u10e1 \u10de\u10e0\u10dd\u10ea\u10d4\u10d3\u10e3\u10e0\u10d4\u10d1\u10d8\u10d7, \u10e1\u10d8\u10d7\u10ee\u10d8\u10e1 \u10e9\u10d0\u10dc\u10d0\u10ea\u10d5\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10f0\u10d4\u10db\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10ee\u10d0\u10e0\u10d3\u10d0\u10ed\u10d4\u10e0\u10d0, \u10e1\u10d8\u10e1\u10ee\u10da\u10d8\u10e1 \u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10e2\u10d4\u10d1\u10d8 (\u10d4\u10e0\u10d8\u10d7\u10e0\u10dd\u10ea\u10d8\u10e2\u10e3\u10da\u10d8 \u10db\u10d0\u10e1\u10d0 \u10d0\u10dc \u10d0\u10ee\u10da\u10d0\u10d3 \u10d2\u10d0\u10e7\u10d8\u10dc\u10e3\u10da\u10d8 \u10de\u10da\u10d0\u10d6\u10db\u10d0, \u10d7\u10d0\u10dc\u10db\u10ee\u10da\u10d4\u10d1\u10d8 \u10d0\u10dc\u10d4\u10db\u10d8\u10d8\u10e1 \u10d0\u10dc \u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10dd\u10de\u10d0\u10d7\u10d8\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7) \u10d0\u10dc \u10d7\u10e0\u10dd\u10db\u10d1\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8.<\/p>\n<p>\u10d8\u10db \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8, \u10d7\u10e3 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8 \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d8 \u10d6\u10dd\u10db\u10d4\u10d1\u10d8\u10d7 \u10e8\u10d4\u10e3\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0, \u10d8\u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d0 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10e1\u10de\u10d4\u10ea\u10d8\u10e4\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d5\u10d4\u10e0\u10e1\u10e3\u10da\u10d8 \u10d0\u10d2\u10d4\u10dc\u10e2\u10d8 (\u10d0\u10dc\u10d3\u10d4\u10e5\u10e1\u10d0\u10dc\u10d4\u10e2 \u10d0\u10da\u10e4\u10d0), \u10d0\u10dc \u10e1\u10de\u10d4\u10ea\u10d8\u10e4\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10dc\u10e2\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10de\u10e0\u10dd\u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10e3\u10da\u10d8 \u10d9\u10dd\u10db\u10de\u10da\u10d4\u10e5\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10e2\u10d8 (PCC), \u10d0\u10e5\u10e2\u10d8\u10d5\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d7\u10e0\u10dd\u10db\u10d1\u10d8\u10dc\u10e3\u10da\u10d8 \u10d9\u10dd\u10db\u10de\u10da\u10d4\u10e5\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10e2\u10d8\u00a0 (APCC)\u00a0 \u10d0\u10dc \u10e0\u10d4\u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d0\u10dc\u10e2\u10e3\u10da\u10d8 VIIa \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8 (r-FVIIa). \u10d7\u10e3\u10db\u10ea\u10d0, \u10d0\u10db\u10df\u10d0\u10db\u10d0\u10d3 \u10d0\u10db \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1, \u10eb\u10d0\u10da\u10d8\u10d0\u10dc \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8\u10d0. \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d4\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10d0 \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da \u10d0\u10e0\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10e1. \u10e0\u10d4\u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d0\u10dc\u10e2\u10e3\u10da\u10d8 VIIa\u00a0 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d4\u10dd\u10e0\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d3\u10dd\u10d6\u10d8\u10e1 \u10e2\u10d8\u10e2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10ee\u10dd\u10e0\u10ea\u10d8\u10d4\u10da\u10d3\u10d4\u10e1 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d3\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7. \u10d0\u10d3\u10d2\u10d8\u10da\u10dd\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ee\u10d4\u10da\u10db\u10d8\u10e1\u10d0\u10ec\u10d5\u10d3\u10dd\u10db\u10dd\u10d1\u10d8\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4, \u10eb\u10da\u10d8\u10d4\u10e0\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d3\u10d4\u10dc\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e1\u10de\u10d4\u10ea\u10d8\u10d0\u10da\u10d8\u10e1\u10e2\u10d7\u10d0\u10dc \u10d9\u10dd\u10dc\u10e1\u10e3\u10da\u10e2\u10d0\u10ea\u10d8\u10d0.<\/p>\n<p>\u10de\u10e0\u10dd\u10e2\u10d0\u10db\u10d8\u10dc \u10e1\u10e3\u10da\u10e4\u10d0\u10e2\u10d8 \u10d3\u10d0 K \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8 \u10d0\u10e0 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10e1 \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u10e1 \u10d0\u10dc\u10e2\u10d8\u10d9\u10dd\u10d0\u10d2\u10e3\u10da\u10d0\u10ea\u10d8\u10e3\u10e0 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d0\u10d6\u10d4. \u10db\u10dd\u10d6\u10e0\u10d3\u10d8\u10da\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10e6\u10d4\u10d1\u10e3\u10da\u10dd\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1, \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8\u10d0 \u10e2\u10e0\u10d0\u10dc\u10d4\u10e5\u10e1\u10d0\u10db\u10d8\u10e1 \u10db\u10df\u10d0\u10d5\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0, \u10d3\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d0\u10db\u10d8\u10dc\u10dd\u10d9\u10d0\u10de\u10e0\u10dd\u10dc\u10db\u10df\u10d0\u10d5\u10d0\u10e1 \u10d3\u10d0 \u10d0\u10de\u10e0\u10dd\u10e2\u10d8\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0. \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d0\u10db \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1. \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d0\u10e0\u10ea \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10e3\u10da\u10d8 \u10d3\u10d0\u10e1\u10d0\u10d1\u10e3\u10d7\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d0\u10e0\u10ea \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10f0\u10d4\u10db\u10dd\u10e1\u10e2\u10d0\u10d6\u10e3\u10e0\u10d8 \u10d3\u10d4\u10e1\u10db\u10dd\u10de\u10e0\u10d4\u10e1\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d8\u10db \u10de\u10d8\u10e0\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10e6\u10d4\u10d1\u10d4\u10dc \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10e1. \u10de\u10da\u10d0\u10d6\u10db\u10d8\u10e1 \u10ea\u10d8\u10da\u10d4\u10d1\u10d7\u10d0\u10dc \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 \u10d0\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10dd\u10e4\u10d0 \u10d3\u10d8\u10d0\u10da\u10d8\u10d6\u10d8\u10d7.<\/p>\n<p><strong>\u10d5\u10d0\u10e0\u10d2\u10d8\u10e1\u10d8\u10d0\u10dc\u10dd\u10d1\u10d8\u10e1 \u10d5\u10d0\u10d3\u10d0<\/strong><\/p>\n<p>30 \u10d7\u10d5\u10d4<\/p>\n<p><strong>\u10e8\u10d4\u10dc\u10d0\u10ee\u10d5\u10d8\u10e1\u00a0 \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10d8 <\/strong><\/p>\n<p>\u10d8\u10dc\u10d0\u10ee\u10d4\u10d1\u10d0 \u10d0\u10e0\u10d0\u10e3\u10db\u10d4\u10e2\u10d4\u10e1 25<sup>0<\/sup>C \u10e2\u10d4\u10db\u10de\u10d4\u10e0\u10d0\u10e2\u10e3\u10e0\u10d0\u10d6\u10d4.<\/p>\n<p>\u10e8\u10d4\u10d8\u10dc\u10d0\u10ee\u10d4\u10d7 \u10d1\u10d0\u10d5\u10e8\u10d5\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10d8\u10e3\u10ec\u10d5\u10d3\u10dd\u10db\u10d4\u10da \u10d0\u10d3\u10d2\u10d8\u10da\u10d0\u10e1.<\/p>\n<p><strong>\u10e8\u10d4\u10e4\u10e3\u10d7\u10d5\u10d0<\/strong><\/p>\n<p>2&#215;14 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8 \u10d3\u10d0\u10e4\u10d0\u10e1\u10dd\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 Alu\/PVC \u10d1\u10da\u10d8\u10e1\u10e2\u10d4\u10e0\u10d6\u10d4, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d8\u10dc\u10e1\u10e2\u10e0\u10e3\u10e5\u10ea\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10db\u10dd\u10d7\u10d0\u10d5\u10e1\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10db\u10e3\u10e7\u10d0\u10dd\u10e1 \u10d9\u10dd\u10da\u10dd\u10e4\u10e8\u10d8.<\/p>\n<p><strong>\u10d2\u10d0\u10ea\u10d4\u10db\u10d8\u10e1 \u10e0\u10d4\u10df\u10d8\u10db\u10d8:<\/strong><\/p>\n<p>\u10e4\u10d0\u10e0\u10db\u10d0\u10ea\u10d4\u10d5\u10e2\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d3\u10e3\u10e5\u10e2\u10d8\u10e1 \u10ef\u10d2\u10e3\u10e4\u10d8 &#8211; II, \u10d2\u10d0\u10d8\u10ea\u10d4\u10db\u10d0 \u10e4\u10dd\u10e0\u10db\u10d0 \u21163 \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10d8\u10d7<\/p>\n<p><strong>\u10db\u10ec\u10d0\u10e0\u10db\u10dd\u10d4\u10d1\u10d4\u10da\u10d8<\/strong><\/p>\n<p>\u10e8\u10de\u10e1 Remus Pharmaceuticals, \u10d8\u10dc\u10d3\u10dd\u10d4\u10d7\u10d8<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0 \u10f0\u10d4\u10db\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8 10\u10db\u10d2 \u10d4\u10e0\u10d7\u10d8 \u10e8\u10d4\u10db\u10dd\u10d2\u10d0\u10e0\u10e1\u10e3\u10da\u10d8 \u10e2\u10d0\u10d1\u10da\u10d4\u10e2\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10d3\u10d2\u10d4\u10dc\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10e8\u10d4\u10d3\u10d8\u10e1: \u10e0\u10d8\u10d5\u10d0\u10e0\u10dd\u10e5\u10e1\u10d0\u10d1\u10d0\u10dc\u10d8\u00a0 BP \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 10\u10db\u10d2 \u10e8\u10d4\u10db\u10d0\u10d5\u10e1\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0q.s. \u10e4\u10d4\u10e0\u10d8: \u10e0\u10d9\u10d8\u10dc\u10d8\u10e1 \u10ec\u10d8\u10d7\u10d4\u10da\u10d8 \u10dd\u10e5\u10e1\u10d8\u10d3\u10d8 \u10d3\u10d0 \u10e2\u10d8\u10e2\u10d0\u10dc\u10d8\u10e1<\/p>\n","protected":false},"featured_media":13223,"template":"","meta":[],"product_brand":[],"product_cat":[],"product_tag":[],"class_list":{"0":"post-13220","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","7":"first","8":"instock","9":"shipping-taxable","10":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/product\/13220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/media\/13223"}],"wp:attachment":[{"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/media?parent=13220"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/product_brand?post=13220"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/product_cat?post=13220"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/newpharma.ge\/en\/wp-json\/wp\/v2\/product_tag?post=13220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}